PAQUID cohort

The PAQUID (or Paquid) cohort is a group of 3,777 individuals aged 65 years or older who were studied from 1988 until present. Researchers chose the group from at least 91 different areas of southwestern France to study the effects of different environmental, behavioral, and social vectors of age-related medical conditions and diseases. One of the major research goals was to determine some of the causes of dementia and Alzheimer's disease like, for example, the correlation between the levels of aluminum in drinking water and the occurrence of dementia.^[1]^[2]^[3]

The studies were conducted by the Université Victor-Segalen, Bordeaux 2 (UB2) in Bordeaux, France.

The source of the term is "Personnes Agées QUID," which can be loosely translated from French and Latin as "What about the elderly?"^[4]

References

↑ "Epidemiologic aspects of respiratory aging: contribution of the PAQUID survey". Rev Epidemiol Sante Publique 45 (5): 417–28. October 1997. PMID 9446147.
↑ http://www.neurology.org/cgi/content/abstract/53/9/1953
↑ Rondeau, V; Jacqmin-Gadda, H; Commenges, D; Helmer, C; Dartigues, JF (Feb 2009). "Aluminum and silica in drinking water and the risk of Alzheimer's disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort". Am J Epidemiol 169 (4): 489–96. doi:10.1093/aje/kwn348. PMC 2809081. PMID 19064650.
↑ http://www.pnas.org/content/98/14/8145.abstract

Clinical research and experimental design

Overview	Clinical trial Trial protocols Adaptive clinical trial Academic clinical trials Clinical study design

Controlled study (EBM I to II-1; A to B)	Randomized controlled trial Scientific experiment Blind experiment Open-label trial

Observational study (EBM II-2 to II-3; B to C)	Cross-sectional study vs. Longitudinal study, Ecological study Cohort study Retrospective Prospective Case-control study (Nested case-control study) Case series Case study Case report

Epidemiology/ methods	occurrence: Incidence (Cumulative incidence) Prevalence Point Period association: absolute (Absolute risk reduction, Attributable risk, Attributable risk percent) relative (Relative risk, Odds ratio, Hazard ratio) other: Clinical endpoint Virulence Infectivity Mortality rate Morbidity Case fatality rate Specificity and sensitivity Likelihood-ratios Pre/post-test probability

Trial/test types	In vitro In vivo Animal testing Animal testing on non-human primates First-in-man study Multicenter trial Seeding trial Vaccine trial

Analysis of clinical trials	Risk–benefit ratio Systematic review Replication Meta-analysis

Interpretation of results	Selection bias Survivorship bias Correlation does not imply causation Null result

Category Glossary List of topics

This article is issued from Wikipedia - version of the Thursday, January 07, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

PAQUID cohort

See also

References