P2RY2

Purinergic receptor P2Y, G-protein coupled, 2

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1Z8E

Identifiers

Symbols

P2RY2 ; HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R

External IDs

OMIM: 600041 MGI: 105107 HomoloGene: 1927 IUPHAR: 324 ChEMBL: 4398 GeneCards: P2RY2 Gene

Gene ontology
Molecular function	• receptor activity • ATP binding • G-protein coupled purinergic nucleotide receptor activity • UTP-activated nucleotide receptor activity
Cellular component	• mitochondrion • lysosome • early endosome • cytosol • plasma membrane • integral component of plasma membrane • basolateral plasma membrane • apical plasma membrane
Biological process	• in utero embryonic development • cellular ion homeostasis • phospholipase C-activating G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • aging • positive regulation of neuron projection development • positive regulation of smooth muscle cell migration • sensory perception of pain • negative regulation of ossification • positive regulation of prostaglandin secretion • positive regulation of chemokine production • G-protein coupled purinergic nucleotide receptor signaling pathway • wound healing • regulation of vasodilation • positive regulation of penile erection • positive regulation of mucus secretion • response to growth factor • cellular response to lipopolysaccharide • cellular response to interleukin-1 • cellular response to purine-containing compound
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
73.22 – 73.24 Mb

Chr 7:
101 – 101.01 Mb

PubMed search

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.^[1]^[2]

The product of this gene, P2Y₂ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.^[3]

References

↑ Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT (May 1994). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy". Proc Natl Acad Sci USA 91 (8): 3275–9. doi:10.1073/pnas.91.8.3275. PMC 43559. PMID 8159738.
↑ Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ (Nov 1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708.
↑ "Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2".

External links

"P2Y Receptors: P2Y₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Tokuyama Y, Hara M, Jones EM, et al. (1995). "Cloning of rat and mouse P2Y purinoceptors.". Biochem. Biophys. Res. Commun. 211 (1): 211–8. doi:10.1006/bbrc.1995.1798. PMID 7779087.
Parr CE, Sullivan DM, Paradiso AM, et al. (1995). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 13067. doi:10.1073/pnas.91.26.13067. PMC 45582. PMID 7809171.
Erb L, Lustig KD, Sullivan DM, et al. (1993). "Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10449–53. doi:10.1073/pnas.90.22.10449. PMC 47794. PMID 8248130.
Dasari VR, Sandhu AK, Mills DC, et al. (1996). "Mapping of the P2U purinergic receptor gene to human chromosome 11q 13.5-14.1.". Somat. Cell Mol. Genet. 22 (1): 75–9. doi:10.1007/BF02374378. PMID 8643996.
Sullivan DM, Erb L, Anglade E, et al. (1997). "Identification and characterization of P2Y2 nucleotide receptors in human retinal pigment epithelial cells.". J. Neurosci. Res. 49 (1): 43–52. doi:10.1002/(SICI)1097-4547(19970701)49:1<43::AID-JNR5>3.0.CO;2-D. PMID 9211988.
Bogdanov Y, Rubino A, Burnstock G (1998). "Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart.". Life Sci. 62 (8): 697–703. doi:10.1016/S0024-3205(97)01168-5. PMID 9489506.
Jin J, Dasari VR, Sistare FD, Kunapuli SP (1998). "Distribution of P2Y receptor subtypes on haematopoietic cells.". Br. J. Pharmacol. 123 (5): 789–94. doi:10.1038/sj.bjp.0701665. PMC 1565225. PMID 9535005.
Tai CJ, Kang SK, Cheng KW, et al. (2000). "Expression and regulation of P2U-purinergic receptor in human granulosa-luteal cells.". J. Clin. Endocrinol. Metab. 85 (4): 1591–7. doi:10.1210/jc.85.4.1591. PMID 10770202.
Erb L, Liu J, Ockerhausen J, et al. (2001). "An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction.". J. Cell Biol. 153 (3): 491–501. doi:10.1083/jcb.153.3.491. PMC 2190579. PMID 11331301.
Moore DJ, Chambers JK, Wahlin JP, et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.". Biochim. Biophys. Acta 1521 (1-3): 107–19. doi:10.1016/S0167-4781(01)00291-3. PMID 11690642.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.". J. Invest. Dermatol. 120 (3): 440–7. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858.
Schafer R, Sedehizade F, Welte T, Reiser G (2003). "ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells.". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (2): L376–85. doi:10.1152/ajplung.00447.2002. PMID 12691958.
Seye CI, Yu N, Jain R, et al. (2003). "The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells.". J. Biol. Chem. 278 (27): 24960–5. doi:10.1074/jbc.M301439200. PMID 12714597.
Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.". J. Invest. Dermatol. 120 (6): 1007–15. doi:10.1046/j.1523-1747.2003.12261.x. PMID 12787128.
Greig AV, Linge C, Healy V, et al. (2003). "Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells.". J. Invest. Dermatol. 121 (2): 315–27. doi:10.1046/j.1523-1747.2003.12379.x. PMID 12880424.
Meshki J, Tuluc F, Bredetean O, et al. (2004). "Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor.". Am. J. Physiol., Cell Physiol. 286 (2): C264–71. doi:10.1152/ajpcell.00287.2003. PMID 14613890.
Haserück N, Erl W, Pandey D, et al. (2004). "The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors.". Blood 103 (7): 2585–92. doi:10.1182/blood-2003-04-1127. PMID 14645014.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Adhesion	ADGRG (1 2 3 4 5 6 7)

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

Purinergics

Receptor
(ligands)

P0
(adenine)

Agonists: 8-Aminoadenine
Adenine

P1
(adenosine)

Agonists: 2-(1-Hexynyl)-N-methyladenosine
2-Cl-IB-MECA
2'-MeCCPA
4'-O-β-D-Glucosyl-9-O-(6''-deoxysaccharosyl)olivil
5'-N-ethylcarboxamidoadenosine
Adenosine
ADP
AMP
Apadenoson
ATL-146e
ATP
BAY 60–6583
Binodenoson
Capadenoson
CCPA
CGS-21680
CP-532,903
Evodenoson
GR 79236
LUF-5835
LUF-5845
N⁶-Cyclopentyladenosine
Neladenoson dalanate
Piclidenoson
Regadenoson
SDZ WAG 994
Selodenoson
Sonedenoson
Tecadenoson
UK-432,097

P2
(nucleotide)

P2X (ATP)	Agonists: 2-Me-SATP α,β-Me-ATP Adenosine ADP AMP Ap4A Ap5A ATP ATPγS BzATP Cibacron blue CTP D-β,γ-Me-ATP GTP HT-AMP Ivermectin L-β,γ-Me-ATP MRS-2219 PAPET-ATP UTP Zinc Antagonists: 5-BDBD A-317491 A-438079 A-740003 A-804598 A-839977 AF-353 AZ-10606120 AZ-11645373 BBG Calcium Calmidazolium Chelerythrine Copper Emodin (Rheum officinale) Evans Blue GW-791343 HMA Ip5I isoPPADS JNJ-47965567 KN-04 KN-62 Magnesium MRS-2159 NF-023 NF-110 NF-157 NF-279 NF-449 Oxidized-ATP Phenol Red Phenolphthalein PPADS PPNDS PSB-12062 Puerarin (Radix puerariae) Purotoxin 1 RB-2 Ro 0437626 Ro 51 RO-3 Sodium ferulate (Angelica sinensis, Ligusticum wallichii) Suramin TC-P 262 Tetramethylpyrazine (ligustrazine) (Ligusticum wallichii) TNP-ATP Zinc

P2Y	Agonists: 2-Me-SADP 2-Me-SATP 2-Thio-UTP 5-Br-UDP 5-OMe-UDP α,β-Me-ATP Adenosine ADP ADPβS Ap3A AR-C 67085MX ATP ATPγS CTP dATP Denufosol Diquafosol IDP ITP INS-365 INS-37217 MRS-2365 MRS-2690 MRS-2693 MRS-2768 MRS-2957 MRS-4062 NF-546 PAPET-ATP PSB-0474 PSB-1114 UDP UDPβS UDP-galactose UDP-glucose UDP-N-acetylglucosamine Up3U UTP UTPγS Antagonists: 2-Me-SAMP A3P5PS AMPαS Ap4A AR-C 66096 AR-C 67085MX AR-C 69931MX AR-C 118925XX ATP BzATP C1330-7 Cangrelor Clopidrogel Elinogrel Ip5I MRS-2179 MRS-2211 MRS-2279 MRS-2395 MRS-2500 MRS-2578 NF-157 NF-340 PIT PPADS Prasugrel PSB-0739 RB-2 Regrelor Suramin Ticagrelor Ticlopidine UDP

Transporter
(blockers)

CNTs	6-Hydroxy-7-methoxyflavone Adenosine dMeThPmR Estradiol KGO-2142 KGO-2173 MeThPmR Phloridzin Progesterone

ENTs	Barbiturates Benzodiazepines Cilostazol Dilazep Dipyridamole Estradiol Ethanol Hexobendine NBMPR Pentoxifylline Progesterone Propentofylline

PMAT	Decynium-22

Enzyme
(inhibitors)

XO	Allopurinol Amflutizole Benzbromarone Caffeic acid Cinnamaldehyde Cinnamomum osmophloeum Febuxostat Myo-inositol Kaempferol Myricetin Niraxostat Oxypurinol Phytic acid Pistacia integerrima Propolis Quercetin Tisopurine Topiroxostat

Others	Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others

Others

Others: Chrysophanol (rhubarb)

This article is issued from Wikipedia - version of the Wednesday, September 02, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

P2RY2

See also

References

External links

Further reading