P2RY14
P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.[1]
The product of this gene, P2Y14 belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.[1]
See also
References
Further reading
- Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annu. Rev. Immunol. 12: 775–808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297.
- Müller CE (2003). "P2-pyrimidinergic receptors and their ligands". Curr. Pharm. Des. 8 (26): 2353–69. doi:10.2174/1381612023392937. PMID 12369950.
- Abbracchio MP, Boeynaems JM, Barnard EA, et al. (2003). "Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family". Trends Pharmacol. Sci. 24 (2): 52–5. doi:10.1016/S0165-6147(02)00038-X. PMID 12559763.
- von Kügelgen I (2006). "Pharmacological profiles of cloned mammalian P2Y-receptor subtypes". Pharmacol. Ther. 110 (3): 415–32. doi:10.1016/j.pharmthera.2005.08.014. PMID 16257449.
- Brunschweiger A, Müller CE (2006). "P2 receptors activated by uracil nucleotides--an update". Curr. Med. Chem. 13 (3): 289–312. doi:10.2174/092986706775476052. PMID 16475938.
- Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
- Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
- Charlton ME, Williams AS, Fogliano M, et al. (1997). "The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge". Brain Res. 764 (1–2): 141–8. doi:10.1016/S0006-8993(97)00438-1. PMID 9295203.
- Joensuu T, Hämäläinen R, Lehesjoki AE, et al. (2000). "A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q". Genomics 63 (3): 409–16. doi:10.1006/geno.1999.6096. PMID 10704288.
- Chambers JK, Macdonald LE, Sarau HM, et al. (2000). "A G protein-coupled receptor for UDP-glucose". J. Biol. Chem. 275 (15): 10767–71. doi:10.1074/jbc.275.15.10767. PMID 10753868.
- Wittenberger T, Schaller HC, Hellebrand S (2001). "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors". J. Mol. Biol. 307 (3): 799–813. doi:10.1006/jmbi.2001.4520. PMID 11273702.
- Joensuu T, Hämäläinen R, Yuan B, et al. (2001). "Mutations in a Novel Gene with Transmembrane Domains Underlie Usher Syndrome Type 3". Am. J. Hum. Genet. 69 (4): 673–84. doi:10.1086/323610. PMC 1226054. PMID 11524702.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lazarowski ER, Shea DA, Boucher RC, Harden TK (2003). "Release of cellular UDP-glucose as a potential extracellular signaling molecule". Mol. Pharmacol. 63 (5): 1190–7. doi:10.1124/mol.63.5.1190. PMID 12695547.
- Lee BC, Cheng T, Adams GB, et al. (2003). "P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrowhematopoietic stem cells". Genes Dev. 17 (13): 1592–604. doi:10.1101/gad.1071503. PMC 196132. PMID 12842911.
- Skelton L, Cooper M, Murphy M, Platt A (2003). "Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose". J. Immunol. 171 (4): 1941–9. doi:10.4049/jimmunol.171.4.1941. PMID 12902497.
- Moore DJ, Murdock PR, Watson JM, et al. (2004). "GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function". Brain Res. Mol. Brain Res. 118 (1–2): 10–23. doi:10.1016/S0169-328X(03)00330-9. PMID 14559350.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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External links
- "P2Y Receptors: P2Y14". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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