Oxfendazole

Oxfendazole
Systematic (IUPAC) name

Methyl N-[6-(benzenesulfinyl)-1H-1,3-benzodiazol-2-yl]carbamate
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	53716-50-0
ATCvet code	QP52AC02
PubChem	CID 40854
ChemSpider	37316
UNII	OMP2H17F9E^Y
ChEMBL	CHEMBL42442
Chemical data
Formula	C₁₅H₁₃N₃O₃S
Molar mass	315.3 g/mol

Oxfendazole is a broad spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against roundworm, strongyles and pinworms.^[1] Oxfendazole is the sulfoxide metabolite of fenbendazole,

Oxfendazole is an anthelmintic (wormer) compound used in veterinary practice. It comes under the chemical class of the benzimidazoles. This drug is barely used in horses, goats, sheep, and cattle. It is very scarcely applied on dogs and cats. The drug for livestock is majorly available in the form of pills, tablets, drenches, bolus, etc. They are meant for oral consumption. Several drenches are allowed for intraruminal injection in some of the countries. Few countries also prefer injectables and pour-ons. For pet dogs, the drug is available in the form of drenches.

Efficacy

Both oxfendazole and fenbendazole are efficacious against gastrointestinal lungworms and roundworms of livestock, adults, and L4-larvae of the significant species for example, of the genera Bunostomum, Haemonchus, Ostertagia, Oesophagostomum, Nematodirus, Teladorsagia, Cooperia, Trichostrongylus, Dictyocaulus, Trichuris, etc, including against arrested larvae of some of the species. They are even highly efficient against majority of the livestock tapeworms. This drug works effectively against the main parasitic roundworms and tapeworms of dogs and cats.

The drug offers a small residual effect in ruminants unless and otherwise it is delivered by using a slow-release device. This essentially means that on a single administration it will help in killing the parasites which are present in the host during the time of treatment and also prevent against re-infestations for some more days but not weeks or months. The residual effect is comparatively shorter in non-ruminants. The drug is non-effective against flukes and external parasites at therapeutic dose.

References

↑ http://www.chemicalland21.com/lifescience/phar/OXFENDAZOLE.htm

Antiparasitics – Anthelmintics (P02) and Endectocides (QP54)

Antiplatyhelmintic agents

Antitrematodals
(schistosomicides)

Binds tubulin	benzimidazole Triclabendazole^#

AI	phosphonic acid Metrifonate^‡

Other/unknown	quinoline Praziquantel^# Oxamniquine^# phenol Bithionol thiazole Niridazole arylsulfonate Stibophen

Anticestodals
(taeniacides)

Binds tubulin	benzimidazole Albendazole^#

Other/unknown	quinoline Praziquantel^# salicylanilide Niclosamide^# aminoacridine Quinacrine butyrophenone Desaspidin chlorophenol Dichlorophen

Antinematodal agents
(including
macrofilaricides)

Binds tubulin	benzimidazole Mebendazole^# Albendazole^# Tiabendazole Fenbendazole Ciclobendazole Flubendazole

Glutamate-gated chloride channel, GABA receptor	avermectins Abamectin Doramectin Emamectin Ivermectin^# Selamectin milbemycins Moxidectin Milbemycin oxime

NMDA	tetrahydropyrimidine Pyrantel^# pyrantel pamoate Oxantel

Other/unknown	piperazine Piperazine Diethylcarbamazine^# thiazole Levamisole^‡# quinolinium Pyrvinium benzylammonium Bephenium naphthalenesulfonate Suramin^# Tribendimidine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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