Optochin

Optochin

Names
IUPAC name (4β,8α,9R)-6'-Ethoxy-10,11-dihydrocinchonan-9-ol
Other names Ethylhydrocupreine
Identifiers
CAS Number	522-60-1 Y
ChEBI	CHEBI:86455 N
ChEMBL	ChEMBL534999 N
ChemSpider	79283 N
Jmol interactive 3D	Image
MeSH	Optochin
PubChem	71542
InChI InChI=1S/C21H28N2O2/c1-3-14-13-23-10-8-15(14)11-20(23)21(24)17-7-9-22-19-6-5-16(25-4-2)12-18(17)19/h5-7,9,12,14-15,20-21,24H,3-4,8,10-11,13H2,1-2H3/t14-,15-,20-,21+/m0/s1 N Key: SUWZHLCNFQWNPE-LATRNWQMSA-N N InChI=1/C21H28N2O2/c1-3-14-13-23-10-8-15(14)11-20(23)21(24)17-7-9-22-19-6-5-16(25-4-2)12-18(17)19/h5-7,9,12,14-15,20-21,24H,3-4,8,10-11,13H2,1-2H3/t14-,15-,20-,21+/m0/s1 Key: SUWZHLCNFQWNPE-LATRNWQMBV
SMILES CC[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c3ccnc4c3cc(cc4)OCC)O
Properties
Chemical formula	C21H28N2O2
Molar mass	340.46 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Optochin (or ethylhydrocupreine) is a chemical used in cell culture techniques for the presumptive identification of Streptococcus pneumoniae, which is optochin-sensitive, from other alpha-hemolytic streptococci such as Streptococcus viridans, which are resistant. A common mnemonic is "OVRPS" (Optochin - Viridans [are] Resistant, Pneumoniae [are] Sensitive). Or "VROPS" (Viridans Resistant [to] Optochin, Pneumoniae Sensitive)

The growth of bacteria that are optochin-sensitive will be inhibited around an optochin disc, while the growth of bacteria that are optochin-resistant will not be affected. In vitro, a solution of as little as 1:10,000,000 may be inhibitory to the pneumococcus, and 1:500,000 is bactericidal.^[1]

Resistance

Strains of Streptococcus pneumoniae have been found to be resistant to optochin in laboratory testing.^[2]

See also

• Quinine

References