Oesophagogastric junctional adenocarcinoma

Oesophagogastric junctional adenocarcinoma is a cancer of the lower part of the oesophagus, often linked to a Barrett's oesophagus.

The incidence of oesophagogastric junctional adenocarcinoma is rising rapidly in western countries, in contrast to the declining frequency of distal gastric adenocarcinoma. Treatment options for adenocarcinomas involving the oesophagogastric junction are limited and the overall prognosis is extremely poor.

Oncogenetics

OGJ adenocarcinoma is a highly mutated and heterogeneous disease. Microsatellite instability (MSI) can be observed and coincides with an elevated number of somatic mutations. Potentially actionable coding mutations have been identified in 67 genes, including those in CR2, HGF, FGFR4 and ESRRB. Numerous genes harbouring somatic coding mutations and copy number changes in the microsatellite stable (MSS) OGJA are also known to be altered with similar predicted functional consequence in other tumour types. TP53, SYNE1, and ARID1A are amongst the most frequently mutated genes. ^[1]

References

↑ Chong, I. Y.; Cunningham, D; Barber, L. J.; Campbell, J; Chen, L; Kozarewa, I; Fenwick, K; Assiotis, I; Guettler, S; Garcia-Murillas, I; Awan, S; Lambros, M; Starling, N; Wotherspoon, A; Stamp, G; Gonzalez-De-Castro, D; Benson, M; Chau, I; Hulkki, S; Nohadani, M; Eltahir, Z; Lemnrau, A; Orr, N; Rao, S; Lord, C. J.; Ashworth, A (2013). "The genomic landscape of oesophagogastric junctional adenocarcinoma". The Journal of pathology 231 (3): 301–10. PMID 24308032.

External links

Diseases of the digestive system (primarily K20–K93, 530–579)

Upper GI tract

Esophagus	Esophagitis Candidal Eosinophilic Herpetiform Rupture Boerhaave syndrome Mallory-Weiss syndrome UES Zenker's diverticulum LES Barrett's esophagus Esophageal motility disorder Nutcracker esophagus Achalasia Diffuse esophageal spasm Gastroesophageal reflux disease (GERD) Laryngopharyngeal reflux (LPR) Esophageal stricture Megaesophagus

Stomach	Gastritis Atrophic Ménétrier's disease Gastroenteritis Peptic (gastric) ulcer Cushing ulcer Dieulafoy's lesion Dyspepsia Pyloric stenosis Achlorhydria Gastroparesis Gastroptosis Portal hypertensive gastropathy Gastric antral vascular ectasia Gastric dumping syndrome Gastric volvulus

Lower GI tract:
Intestinal/
Enteropathy

Small intestine (Duodenum/Jejunum/Ileum)	Enteritis Duodenitis Jejunitis Ileitis Peptic (duodenal) ulcer Curling's ulcer Malabsorption: Coeliac Tropical sprue Blind loop syndrome Small bowel bacterial overgrowth syndrome Whipple's Short bowel syndrome Steatorrhea Milroy disease bile acid malabsorption

Large intestine (Appendix/Colon)	Appendicitis Colitis Pseudomembranous Ulcerative Ischemic Microscopic Collagenous Lymphocytic Functional colonic disease IBS Intestinal pseudoobstruction / Ogilvie syndrome Megacolon / Toxic megacolon Diverticulitis/Diverticulosis

Large and/or small	Enterocolitis Necrotizing Gastroenterocolitis IBD Crohn's disease Vascular: Abdominal angina Mesenteric ischemia Angiodysplasia Bowel obstruction: Ileus Intussusception Volvulus Fecal impaction Constipation Diarrhea Infectious Intestinal adhesions

Rectum	Proctitis Radiation proctitis Proctalgia fugax Rectal prolapse Anismus

Anal canal	Anal fissure/Anal fistula Anal abscess Anal dysplasia Pruritus ani

GI bleeding/BIS

Accessory

Liver	Hepatitis Viral hepatitis Autoimmune hepatitis Alcoholic hepatitis Cirrhosis PBC Fatty liver NASH Vascular Budd-Chiari syndrome Hepatic veno-occlusive disease Portal hypertension Nutmeg liver Alcoholic liver disease Liver failure Hepatic encephalopathy Acute liver failure Liver abscess Pyogenic Amoebic Hepatorenal syndrome Peliosis hepatis Metabolic disorders Wilson's Disease Hemochromatosis

Gallbladder	Cholecystitis Gallstones/Cholecystolithiasis Cholesterolosis Rokitansky-Aschoff sinuses Postcholecystectomy syndrome Porcelain gallbladder

Bile duct/ Other biliary tree	Cholangitis Primary sclerosing cholangitis Secondary sclerosing cholangitis Ascending Cholestasis/Mirizzi's syndrome Biliary fistula Haemobilia Gallstones/Cholelithiasis Common bile duct Choledocholithiasis Biliary dyskinesia Sphincter of Oddi dysfunction

Pancreatic	Pancreatitis Acute Chronic Hereditary Pancreatic abscess Pancreatic pseudocyst Exocrine pancreatic insufficiency Pancreatic fistula

Abdominopelvic

Hernia	Diaphragmatic Congenital Hiatus Inguinal Indirect Direct Umbilical Femoral Obturator Spigelian Lumbar Petit's Grynfeltt-Lesshaft Undefined location Incisional Internal hernia

Peritoneal	Peritonitis Spontaneous bacterial peritonitis Hemoperitoneum Pneumoperitoneum

Digestive system neoplasia (C15–C26/D12–D13, 150–159/211)

GI tract

Upper

Esophagus	Squamous cell carcinoma Adenocarcinoma

Stomach	Gastric carcinoma Signet ring cell carcinoma Gastric lymphoma MALT lymphoma Linitis plastica

Lower

Small intestine	Duodenal cancer Adenocarcinoma

Appendix	Carcinoid Pseudomyxoma peritonei

Colon/rectum	colorectal polyp: Peutz–Jeghers syndrome Juvenile polyposis syndrome Familial adenomatous polyposis/Gardner's syndrome Cronkhite–Canada syndrome neoplasm: Adenocarcinoma Familial adenomatous polyposis Hereditary nonpolyposis colorectal cancer

Anus	Squamous cell carcinoma

Upper and/or lower

Accessory

Liver	malignant: Hepatocellular carcinoma Fibrolamellar Hepatoblastoma benign: Hepatocellular adenoma Cavernous hemangioma hyperplasia: Focal nodular hyperplasia Nodular regenerative hyperplasia

Biliary tract	bile duct: Cholangiocarcinoma Klatskin tumor gallbladder: Gallbladder cancer

Pancreas	exocrine pancreas: Adenocarcinoma Pancreatic ductal carcinoma cystic neoplasms: Serous microcystic adenoma Intraductal papillary mucinous neoplasm Mucinous cystic neoplasm Solid pseudopapillary neoplasm Pancreatoblastoma

Peritoneum

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