Oncostatin M receptor
| Oncostatin M receptor | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | OSMR ; OSMRB; PLCA1 | ||||||||||||
| External IDs | OMIM: 601743 MGI: 1330819 HomoloGene: 2972 IUPHAR: 1714 GeneCards: OSMR Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9180 | 18414 | |||||||||||
| Ensembl | ENSG00000145623 | ENSMUSG00000022146 | |||||||||||
| UniProt | Q99650 | O70458 | |||||||||||
| RefSeq (mRNA) | NM_001168355 | NM_011019 | |||||||||||
| RefSeq (protein) | NP_001161827 | NP_035149 | |||||||||||
| Location (UCSC) |
Chr 5: 38.85 – 38.95 Mb |
Chr 15: 6.81 – 6.87 Mb | |||||||||||
| PubMed search | |||||||||||||
Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor, is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene.[1][2]
OSMR is a member of the type I cytokine receptor family. This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events.[1]
Clinical significance
The oncostatin M receptor is associated with primary cutaneous amyloidosis.[3]
References
- 1 2 "Entrez Gene: oncostatin M receptor".
- ↑ Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. PMID 8999038.
- ↑ Arita K, South AP, Hans-Filho G, et al. (January 2008). "Oncostatin M Receptor-β Mutations Underlie Familial Primary Localized Cutaneous Amyloidosis". Am. J. Hum. Genet. 82 (1): 73–80. doi:10.1016/j.ajhg.2007.09.002. PMC 2253984. PMID 18179886.
External links
- Oncostatin M Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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