OR4F4

Olfactory receptor, family 4, subfamily F, member 4
Identifiers
Symbols OR4F4 ; OLA-7501; OR4F18
External IDs HomoloGene: 128250 GeneCards: OR4F4 Gene
Orthologs
Species Human Mouse
Entrez 26682 623583
Ensembl ENSG00000177693 ENSMUSG00000044039
UniProt Q96R69 Q7TQY0
RefSeq (mRNA) NM_001004195 NM_146400.2
RefSeq (protein) NP_001004195 NP_666512.2
Location (UCSC) Chr 15:
101.92 – 101.92 Mb		 Chr 2:
111.32 – 111.32 Mb
PubMed search

Olfactory receptor 4F4 is a protein that in humans is encoded by the OR4F4 gene.[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]

See also

References

  1. 1 2 "Entrez Gene: OR4F4 olfactory receptor, family 4, subfamily F, member 4".

Further reading

  • Trask BJ, Friedman C, Martin-Gallardo A, et al. (1998). "Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes.". Hum. Mol. Genet. 7 (1): 13–26. doi:10.1093/hmg/7.1.13. PMID 9384599. 
  • Mefford HC, Linardopoulou E, Coil D, et al. (2002). "Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.". Hum. Mol. Genet. 10 (21): 2363–72. doi:10.1093/hmg/10.21.2363. PMID 11689483. 
  • Linardopoulou E, Mefford HC, Nguyen O, et al. (2002). "Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.". Hum. Mol. Genet. 10 (21): 2373–83. doi:10.1093/hmg/10.21.2373. PMID 11689484. 
  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes.". Genomics 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199. 
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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