OR12D3
| Olfactory receptor, family 12, subfamily D, member 3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | OR12D3 ; hs6M1-27 | ||||||||||||
| External IDs | MGI: 2177492 HomoloGene: 12811 GeneCards: OR12D3 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 81797 | 258832 | |||||||||||
| Ensembl | ENSG00000229181 | ENSMUSG00000029184 | |||||||||||
| UniProt | Q9UGF7 | Q8VG96 | |||||||||||
| RefSeq (mRNA) | NM_030959 | NM_146835 | |||||||||||
| RefSeq (protein) | NP_112221 | NP_667046 | |||||||||||
| Location (UCSC) |
Chr 6: 29.37 – 29.38 Mb |
Chr 17: 37.47 – 37.47 Mb | |||||||||||
| PubMed search | |||||||||||||
Olfactory receptor 12D3 is a protein that in humans is encoded by the OR12D3 gene.[1]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]
See also
References
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes.". J. Biol. Chem. 278 (22): 19691–701. doi:10.1074/jbc.M212424200. PMID 12637542.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family.". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Santos PS, Füst G, Prohászka Z, et al. (2008). "Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex.". Genet Test. 12 (4): 481–6. doi:10.1089/gte.2008.0029. PMC 2635552. PMID 18939942.
- Santos PS, Kellermann T, Uchanska-Ziegler B, et al. (2010). "Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species.". Immunogenetics. 62 (9): 569–84. doi:10.1007/s00251-010-0468-6. PMID 20680261.
External links
- OR12D3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||