List of people named O'Brien
O'Brien is a surname of Irish origin which has many variants in the Irish diaspora worldwide, such as O'Bryan, O'Brian, O'Briant, O'Brient, O'Bryant, O'Brine, O'Bryen etc., which all claim a general common ancestry with the original Gaelic surname being Ó Briain or Uí Briain. Notable people with the surname include:
Real people
- Aidan O'Brien (b. 1969), Irish race horse trainer
- Alan O'Brien, Irish association football player
- Alex O'Brien (b. 1970), professional American tennis player
- Ambrose O'Brien
- Andy O'Brien (disambiguation), various
- Andy O'Brien (footballer), Irish association football player
- Anne O'Brien (disambiguation), various
- Anne O'Brien (athlete) (1911–2007), American track and field athlete
- Arthur O'Brien
- Austin O'Brien
- Barry O'Brien
- Billy O'Brien (1860–1911), American baseball player
- Brendan O'Brien (disambiguation), various
- Brenna O'Brien
- Brock O'Brien
- Buck O'Brien
- Burton O'Brien
- Cathy O'Brien (conspiracy theorist) (b. 1957), purported American child-slave/sex-abuse victim
- Cathy O'Brien (athlete) (b. 1967), American long-distance runner
- Charles O'Brien (disambiguation), various
- Christian O'Brien (1914-2001), British geologist, author & historian
- Ciaran O'Brien
- Cinders O'Brien
- Clinton O'Brien (b. 1974), Australian rugby league footballer
- Conal O'Brien
- Conan O'Brien (b. 1963), US comedian and talk show host
- Connor O'Brien (disambiguation)
- Connor O'Brien, King of Thomond (died 1540)
- Connor O'Brien, 3rd Earl of Thomond (1534?–1581)
- Connor O'Brien, 2nd Viscount Clare (1605–1670)
- Connor O'Brien (alpine skier) (born 1961), Canadian alpine skier
- Conor O'Brien (disambiguation), various
- Cubby O'Brien
- Daniel O'Brien (disambiguation), various
- Daniel O'Brien, 1st Viscount Clare Irish member of the confederation of Kilkenny
- Daniel O'Brien, 3rd Viscount Clare
- Daniel O'Brien, 4th Viscount Clare
- Danielle O'Brien
- Danny O'Brien (disambiguation), various
- Dara Ó Briain, Irish comedian and presenter
- Darcy O'Brien (1939–1998), American true crime author
- Daryl O'Brien (b. 1941), Australian footballer (Australian rules football)
- Dave O'Brien (sportscaster), American sportscaster
- Dave O'Brien (actor) (1912–1969), American film actor
- David O'Brien (disambiguation), various
- Declan O'Brien, president of Utopia Pictures & Television, and a writer and producer
- Declan O'Brien (footballer)
- Dennis O'Brien (disambiguation), various
- Derek O'Brien (disambiguation), various
- Dermod O'Brien (1865–1906), Irish painter
- Donald O'Brien (disambiguation), various
- Doug O'Brien
- Dylan O'Brien (b. 1991), American actor
- Ed O'Brien, (b. 1968), English musician
- Edmond O'Brien
- Edna O'Brien (b. 1930), Irish novelist
- Edward O'Brien (disambiguation), various
- Edward O'Brien (Irish republican) (1974–1996), Provisional Irish Republican Army (IRA) volunteer
- Edwin Frederick O'Brien, Grand Master of the Equestrian Order of the Holy Sepulchre of Jerusalem
- Eileen O'Brien (disambiguation), various
- Elaine O'Brien, American politician
- Erin Joanne O'Brien (b. 1935), American actress
- Erin O'Brien (writer), American writer
- Eugene O'Brien (disambiguation), various
- Eugene O'Brien (actor), actor of the silent film era
- Eugene O'Brien (racing driver), British auto racing driver
- Fergal O'Brien, Irish professional snooker player
- Fergus O'Brien
- Fitz James O'Brien, Irish born American novelist
- Flann O'Brien, pen name of Irish novelist and satirist Brian O'Nolan
- Gareth O'Brien
- George O'Brien (disambiguation), various
- George O'Brien (actor) (1899–1985), American silent movie actor
- George O'Brien (cricketer) (b. 1984), Bermudian cricketer
- George O'Brien (footballer) (b. 1935), former Southampton F.C. footballer
- George O'Brien (painter) (1821–1888), New Zealand painter
- George O'Brien (captain) (1788–1818), Irish, former lieutenant of the British Royal Navy, died in combat, fighting for the Independence of Chile
- George Thomas Michael O'Brien (fl. 1890s – 1900s), former governor of Fiji
- George H. O'Brien, Jr. (1926–2005), Korean War Congressional Medal of Honor Recipient
- George M. O'Brien (1917–1986), member of the U.S. House of Representatives
- Ger O'Brien
- Geoffrey O'Brien
- Glenn O'Brien
- Gray O'Brien
- Harry O'Brien (changed his name in 2013 to "Heritier Lumumba")
- Harvey O'Brien
- Henry O'Brien (disambiguation), various
- Hod O'Brien
- Hugh O'Brien (1827–1895) mayor of Boston
- Iain O'Brien
- Ian O'Brien
- Jack O'Brien (disambiguation), various
- Jake O'Brien
- James O'Brien (disambiguation)
- Jamie O'Brien (disambiguation), various
- Jeremiah O'Brien (1744–1818), US Navy officer of the American Revolutionary War
- Jesse O'Brien (disambiguation), various
- Jim O'Brien (disambiguation)
- Joan O'Brien
- Joey O'Brien
- John O'Brien (disambiguation), various
- John O'Brien (marine artist) (1831–1891), Canadian painter
- John O'Brien (rower), New Zealand rower
- John O'Brien (soccer), American soccer player
- John J. O'Brien, American basketball referee and administrator
- John Thomond O'Brien
- John P. O'Brien, Mayor of New York City
- Joseph O'Brien (disambiguation), various
- Kate O'Brien (disambiguation)
- Kathleen O'Brien
- Katie O'Brien, British female tennis player
- Keith O'Brien, Roman Catholic Cardinal Archbishop of Saint Andrews and Edinburgh. Keith O'Brien, Journeyman Lineman
- Ken O'Brien
- Kerry O'Brien (disambiguation)
- Kevin O'Brien (disambiguation), various
- Kevin O'Brien (Irish football)
- Kevin O'Brien (Texas pastor), Independent Baptist pastor in Texas
- Kieran O'Brien
- Kim O'Brien, American film and television actress
- Kirsten O'Brien (born 1972), British TV presenter
- Kyan Laslett O'Brien Music Composer
- Larry O'Brien (1917–1990), American politician
- Larry O'Brien (Canadian politician), Canadian entrepreneur and politician; Mayor of Ottawa, late 2006 to present
- Laurence O'Brien
- Lawrence O'Brien
- Leighton O'Brien
- Leo O'Brien
- Leslie O'Brien
- Liam O'Brien (disambiguation), various
- Lucy O'Brien
- Luke O'Brien
- Margaret O'Brien
- Mariah O'Brien
- Mark O'Brien (disambiguation), various
- Mark O'Brien (Ontario politician), Green Party candidate in the 2004 Canadian federal election
- Maureen O'Brien
- Michael O'Brien (disambiguation), various
- Michael O'Brien (swimmer) (born 1965), American freestyle swimmer
- Mick O'Brien (musician), Traditional Irish musician
- Mike O'Brien (hurler)
- Miles O'Brien (journalist), journalist and CNN anchor
- Michele O'Brien
- Mick O'Brien (disambiguation), various
- Miles O'Brien (disambiguation), various
- Mollie O'Brien
- Niall O'Brien (disambiguation), various
- Nick O'Brien
- Paddy O'Brien (disambiguation), various
- Parry O'Brien
- Patrick O'Brien (disambiguation), for people with forename Patrick or Pat
- Pat O'Brien (disambiguation), various
- Paul O'Brien (disambiguation), various
- Peter O'Brien (disambiguation), various
- Raymond O'Brien, American Roman Catholic priest
- Richard O'Brien (disambiguation), various
- Richard O'Brien (born 1942), Rocky Horror Picture Show writer and actor
- Richard Baptist O’Brien (1809–1885), Irish priest, author and nationalist
- Robert O'Brien (disambiguation), various
- Robert O'Brien (auto racer), American racing driver
- Robert C. O'Brien (author), pen name of Robert Leslie Conly (1918–1973), American author and journalist
- Ron O'Brien (disambiguation), various
- Roy O'Brien
- Scott O'Brien
- Sean O'Brien (disambiguation)
- Shane O'Brien (disambiguation), various
- Shannon O'Brien
- Shauna O'Brien, American erotic film star
- Simon O'Brien (disambiguation), various
- Soledad O'Brien, American television journalist
- Stephen O'Brien, UK conservative politician for Eddisbury
- Steve O'Brien
- Stuart O'Brien, lead guitarist of rock band Amnezia
- Terence O'Brien (disambiguation), various
- Terence Albert O'Brien (1600–1651), beatified Irish bishop
- Thomas O'Brien (disambiguation), various
- Thomas J. O'Brien (Illinois), Illinois politician
- Thomas J. O'Brien (Massachusetts), Massachusetts State Representative
- Thomas J. O'Brien (Michigan) (1842–1933), Michigan politician and U. S. ambassador
- Tim O'Brien (disambiguation), various
- Tim O'Brien (author) (born 1946), American author
- Tim O'Brien (musician) (born 1954), American musician
- Tim O'Brien (musician) (born 1954), American musician
- Sir Tim O'Brien, 3rd Baronet (1861–1948), Irish-born cricketer
- Tim O'Brien (politician) (born 1968), legislator in the Connecticut House of Representatives
- Tim O'Brien (illustrator) (born 1964), American artist
- Timothy O'Brien (theatre designer) (born 1929), British theatre designer
- Timothy O'Brien (endocrinologist), Irish professor
- Timothy L. O'Brien (born 1961), American journalist
- Tina O'Brien (born 1983), English actress
- Tom O'Brien (UK politician) (1900–1970), British trade unionist and Member of Parliament
- Tom O'Brien (second baseman) (1860–1921), 19th century baseball player
- Tom O'Brien (outfielder) (1873–1901), baseball outfielder
- Tom O'Brien (actor) (b. 1965), American film actor
- Tom O'Brien (football coach) (b. 1948), American college football coach at North Carolina State University
- Tommy O'Brien (1918–1978), baseball outfielder
- Trever O'Brien
- Una O'Brien, British civil servant
- Vincent O'Brien (disambiguation), various
- Vincent O'Brien, Irish race horse trainer
- Virginia O'Brien
- Walter O'Brien, Irish businessman
- Walter A. O'Brien, American Progressive Party politician
- William O'Brien (disambiguation), various
- William O'Brien, Irish Nationalist and politician
- William Smith O'Brien
- Willis O'Brien
- Conor Murphy O'Brien (Died 1478), Killed during Spanish Inquisition with brother Adam Murphy O'Brien.
Fictional people named O'Brien
- O'Brien (1984), a character in George Orwell's Nineteen Eighty-Four
- Keiko O'Brien, fictional character, wife of Miles O'Brien in Star Trek: The Next Generation and Deep Space Nine
- Lady Cassandra O'Brien, fictional character, Doctor Who villainess
- Miles O'Brien (Star Trek), fictional character in Star Trek: The Next Generation and Deep Space Nine
- Sarah O'Brien, fictional character on the ITV series Downton Abbey
See also
- O'Brien dynasty, the royal dynasty who ruled Thomond
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