Nonsteroidal
Nonsteroidal is a term used to describe a compound that is not a steroid and to indicate as such.
It is used in the name of nonsteroidal anti-inflammatory drugs (NSAIDs) to distinguish them from corticosteroids as a class of anti-inflammatory agents.[1]
Nonsteroidal is also used to describe steroidergic drugs that are not steroid derivatives.[2][3] Examples include the following:[2][3]
- Estrogens: benzestrol, DBE, diethylstilbestrol (stilbestrol), dienestrol, fosfestrol, hexestrol (dihydroxystilbestrol), methallenestril, methestrol, methestrol dipropionate, paroxypropione, prinaberel, and triphenylethylene, as well as many xenoestrogens
- SERMs: acolbifene, afimoxifene, arzoxifene, bazedoxifene, broparestrol, chlorotrianisene, clomifene, clomifenoxide, cyclofenil, droloxifene, enclomifene, endoxifen, ethamoxytriphetol, fispemifene, idoxifene, lasofoxifene, levormeloxifene, miproxifene, nafoxidine, nitromifene, ormeloxifene, ospemifene, panomifene, pipendoxifene, raloxifene, sivifene, tamoxifen, tesmilifene, toremifene, trioxifene, zindoxifene, zuclomifene
- Antiandrogens: apalutamide, bicalutamide, cimetidine, enzalutamide, EPI-001, flutamide, hydroxyflutamide, inocoterone, ketoconazole, nilutamide, orteronel, RU-58642, RU-58841, and topilutamide
- SARMs: AC-262,356, andarine, BMS-564,929, enobosarm (ostarine), GW-501516, JNJ-28330835, LGD-2226, LGD-3303, LGD-4033, S-23, and S-40503
- Miscellaneous: tanaproget (progestogen), finerenone (antimineralocorticoid), AZD5423 (glucocorticoid), AL082D06 (antiglucocorticoid), mapracorat (SGRM), and Org 214007-0 (SGRM)
References
- ↑ Buer JK (Oct 2014). "Origins and impact of the term 'NSAID'". Inflammopharmacology 22 (5): 263–7. doi:10.1007/s10787-014-0211-2. PMID 25064056.
- 1 2 Edward J. Pavlik (6 December 2012). Estrogens, Progestins, and Their Antagonists: Health Issues. Springer Science & Business Media. pp. 166–. ISBN 978-1-4612-4096-9.
- 1 2 Thomas Nogrady Professor of Medicinal Chemistry Concordia University (Emeritus); Donald F. Weaver Canada Research Chair and Professor of Medicine and Chemistry Dalhousie University (27 July 2005). Medicinal Chemistry : A Molecular and Biochemical Approach: A Molecular and Biochemical Approach. Oxford University Press, USA. pp. 322–. ISBN 978-0-19-802645-7.
This article is issued from Wikipedia - version of the Saturday, February 06, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.