Nodularin

Nodularin
The 2d structure of the Nodularin-R peptide.
Names
Other names
Cyclo[(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl]
Identifiers
118399-22-7 YesY
KEGG C15713 YesY
Properties
C41H60N8O10
Molar mass 824.98 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY verify (what is YesYN ?)
Infobox references

Nodularin-R is a cyclic nonribosomal peptide produced by the cyanobacterium Nodularia spumigena.[1] This cyanobacterium forms blooms in brackish water bodies throughout the world. The late summer blooms of Nodularia spumigena are among the largest cyanobacterial mass occurrences in the world. Nodularin-R is a cyclic pentapeptide and contains several unusual non-proteinogenic amino acids such as N-methyl-didehydroaminobutyric acid and the β-amino acid ADDA. Nodularin-R is a potent hepatotoxin and may cause serious damage to the liver of humans and other animals.

References

  1. ↑ Sivonen K, Kononen K, Carmichael WW, Dahlem AM, Rinehart KL, Kiviranta J, Niemela SI (1989). "Occurrence of the hepatotoxic cyanobacterium Nodularia spumigena in the Baltic Sea and structure of the toxin". Appl. Environ. Microbiol. 55 (8): 1990–5. PMC 202992. PMID 2506812.

See also

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