Neuropeptide S receptor

Neuropeptide S receptor 1
Identifiers
Symbols NPSR1 ; ASRT2; GPR154; GPRA; NPSR; PGR14; VRR1
External IDs OMIM: 608595 MGI: 2441738 HomoloGene: 45515 IUPHAR: 302 ChEMBL: 5162 GeneCards: NPSR1 Gene
Orthologs
Species Human Mouse
Entrez 387129 319239
Ensembl ENSG00000187258 ENSMUSG00000043659
UniProt Q6W5P4 Q8BZP8
RefSeq (mRNA) NM_001300933 NM_175678
RefSeq (protein) NP_001287862 NP_783609
Location (UCSC) Chr 7:
34.66 – 34.88 Mb		 Chr 9:
24.1 – 24.32 Mb
PubMed search

The neuropeptide S receptor (NPSR) is a member of the G-protein coupled receptor superfamily of integral membrane proteins[1] which binds neuropeptide S (NPS).[2] It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous ligand. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. This gene is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Mutations in this gene have also been associated with this disease.[3]

Clinical significance

In the CNS, activation of the NPSR by NPS promotes arousal and anxiolytic-like effects.[4][5]

In addition, mututations in NPSR have been linked to a susceptibility to asthma.[6] Hence NPSR has also been called GPRA (G protein-coupled receptor for asthma susceptibility). Activation of NPSR in the airway epithelium has a number of effects including upregulation of matrix metalloproteinases which are involved in the pathogenesis of asthma.[7]

References

  1. ↑ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
  2. ↑ Vendelin J, Pulkkinen V, Rehn M, Pirskanen A, Räisänen-Sokolowski A, Laitinen A, Laitinen LA, Kere J, Laitinen T (Sep 2005). "Characterization of GPRA, a novel G protein-coupled receptor related to asthma". American Journal of Respiratory Cell and Molecular Biology 33 (3): 262–70. doi:10.1165/rcmb.2004-0405OC. PMID 15947423.
  3. ↑ "Entrez Gene: NPSR1 neuropeptide S receptor 1".
  4. ↑ Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O (Aug 2004). "Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects". Neuron 43 (4): 487–97. doi:10.1016/j.neuron.2004.08.005. PMID 15312648.
  5. ↑ Okamura N, Reinscheid RK (Aug 2007). "Neuropeptide S: a novel modulator of stress and arousal". Stress 10 (3): 221–6. doi:10.1080/10253890701248673. PMID 17613937.
  6. ↑ Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Mäkelä S, Rehn M, Pirskanen A, Rautanen A, Zucchelli M, Gullstén H, Leino M, Alenius H, Petäys T, Haahtela T, Laitinen A, Laprise C, Hudson TJ, Laitinen LA, Kere J (Apr 2004). "Characterization of a common susceptibility locus for asthma-related traits". Science 304 (5668): 300–4. doi:10.1126/science.1090010. PMID 15073379.
  7. ↑ Vendelin J, Bruce S, Holopainen P, Pulkkinen V, Rytilä P, Pirskanen A, Rehn M, Laitinen T, Laitinen LA, Haahtela T, Saarialho-Kere U, Laitinen A, Kere J (Oct 2006). "Downstream target genes of the neuropeptide S-NPSR1 pathway". Human Molecular Genetics 15 (19): 2923–35. doi:10.1093/hmg/ddl234. PMID 16926187.

Further reading

  • Malerba G, Pignatti PF (2005). "A review of asthma genetics: gene expression studies and recent candidates". Journal of Applied Genetics 46 (1): 93–104. PMID 15741670. 
  • Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517. 
  • Gupte J, Cutler G, Chen JL, Tian H (Feb 2004). "Elucidation of signaling properties of vasopressin receptor-related receptor 1 by using the chimeric receptor approach". Proceedings of the National Academy of Sciences of the United States of America 101 (6): 1508–13. doi:10.1073/pnas.0308250100. PMC 341764. PMID 14757815. 
  • Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Mäkelä S, Rehn M, Pirskanen A, Rautanen A, Zucchelli M, Gullstén H, Leino M, Alenius H, Petäys T, Haahtela T, Laitinen A, Laprise C, Hudson TJ, Laitinen LA, Kere J (Apr 2004). "Characterization of a common susceptibility locus for asthma-related traits". Science 304 (5668): 300–4. doi:10.1126/science.1090010. PMID 15073379. 
  • Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O (Aug 2004). "Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects". Neuron 43 (4): 487–97. doi:10.1016/j.neuron.2004.08.005. PMID 15312648. 
  • Melén E, Bruce S, Doekes G, Kabesch M, Laitinen T, Lauener R, Lindgren CM, Riedler J, Scheynius A, van Hage-Hamsten M, Kere J, Pershagen G, Wickman M, Nyberg F (May 2005). "Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma". American Journal of Respiratory and Critical Care Medicine 171 (10): 1089–95. doi:10.1164/rccm.200410-1317OC. PMID 15710598. 
  • Kormann MS, Carr D, Klopp N, Illig T, Leupold W, Fritzsch C, Weiland SK, von Mutius E, Kabesch M (Jun 2005). "G-Protein-coupled receptor polymorphisms are associated with asthma in a large German population". American Journal of Respiratory and Critical Care Medicine 171 (12): 1358–62. doi:10.1164/rccm.200410-1312OC. PMID 15764725. 
  • Gloriam DE, Schiöth HB, Fredriksson R (Apr 2005). "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochimica et Biophysica Acta 1722 (3): 235–46. doi:10.1016/j.bbagen.2004.12.001. PMID 15777626. 
  • Postma DS, Koppelman GH (Jun 2005). "Confirmation of GPRA: a putative drug target for asthma". American Journal of Respiratory and Critical Care Medicine 171 (12): 1323–4. doi:10.1164/rccm.2503006. PMID 15941840. 
  • Vendelin J, Pulkkinen V, Rehn M, Pirskanen A, Räisänen-Sokolowski A, Laitinen A, Laitinen LA, Kere J, Laitinen T (Sep 2005). "Characterization of GPRA, a novel G protein-coupled receptor related to asthma". American Journal of Respiratory Cell and Molecular Biology 33 (3): 262–70. doi:10.1165/rcmb.2004-0405OC. PMID 15947423. 
  • Söderhäll C, Marenholz I, Nickel R, Grüber C, Kehrt R, Rohde K, Griffioen RW, Meglio P, Tarani L, Gustafsson D, Hoffmann U, Gerstner B, Müller S, Wahn U, Lee YA (Jul 2005). "Lack of association of the G protein-coupled receptor for asthma susceptibility gene with atopic dermatitis". The Journal of Allergy and Clinical Immunology 116 (1): 220–1. doi:10.1016/j.jaci.2005.03.002. PMID 15990798. 
  • Veal CD, Reynolds NJ, Meggitt SJ, Allen MH, Lindgren CM, Kere J, Trembath RC, Barker JN (Aug 2005). "Absence of association between asthma and high serum immunoglobulin E associated GPRA haplotypes and adult atopic dermatitis". The Journal of Investigative Dermatology 125 (2): 399–401. doi:10.1111/j.0022-202X.2005.23828.x. PMID 16098057. 
  • Feng Y, Hong X, Wang L, Jiang S, Chen C, Wang B, Yang J, Fang Z, Zang T, Xu X, Xu X (Mar 2006). "G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population". The Journal of Allergy and Clinical Immunology 117 (3): 612–7. doi:10.1016/j.jaci.2005.11.045. PMID 16522461. 
  • Bernier V, Stocco R, Bogusky MJ, Joyce JG, Parachoniak C, Grenier K, Arget M, Mathieu MC, O'Neill GP, Slipetz D, Crackower MA, Tan CM, Therien AG (Aug 2006). "Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I". The Journal of Biological Chemistry 281 (34): 24704–12. doi:10.1074/jbc.M603691200. PMID 16790440. 
  • Allen IC, Pace AJ, Jania LA, Ledford JG, Latour AM, Snouwaert JN, Bernier V, Stocco R, Therien AG, Koller BH (Nov 2006). "Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease". American Journal of Physiology. Lung Cellular and Molecular Physiology 291 (5): L1005–17. doi:10.1152/ajplung.00174.2006. PMID 16829631. 
  • Vendelin J, Bruce S, Holopainen P, Pulkkinen V, Rytilä P, Pirskanen A, Rehn M, Laitinen T, Laitinen LA, Haahtela T, Saarialho-Kere U, Laitinen A, Kere J (Oct 2006). "Downstream target genes of the neuropeptide S-NPSR1 pathway". Human Molecular Genetics 15 (19): 2923–35. doi:10.1093/hmg/ddl234. PMID 16926187. 
  • Pulkkinen V, Haataja R, Hannelius U, Helve O, Pitkänen OM, Karikoski R, Rehn M, Marttila R, Lindgren CM, Hästbacka J, Andersson S, Kere J, Hallman M, Laitinen T (2007). "G protein-coupled receptor for asthma susceptibility associates with respiratory distress syndrome". Annals of Medicine 38 (5): 357–66. doi:10.1080/07853890600756453. PMID 16938805. 

External links

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