Neuromedin U receptor 2

Identifiers

NMUR2 ; FM-4; FM4; NMU-R2; NMU2R; TGR-1; TGR1

External IDs

OMIM: 605108 MGI: 2441765 HomoloGene: 49618 IUPHAR: 299 ChEMBL: 1075144 GeneCards: NMUR2 Gene

Gene ontology
Molecular function	• neuromedin U receptor activity • G-protein coupled receptor activity • intracellular calcium activated chloride channel activity • protein binding • GTP binding • neuromedin U binding
Cellular component	• intracellular • cytosol • plasma membrane • integral component of membrane
Biological process	• reduction of food intake in response to dietary excess • calcium ion transport • chloride transport • regulation of smooth muscle contraction • phospholipase C-activating G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • neuropeptide signaling pathway • cell-cell signaling • central nervous system development • grooming behavior • feeding behavior • calcium-mediated signaling • activation of phospholipase A2 activity by calcium-mediated signaling • inositol phosphate-mediated signaling • response to pain • arachidonic acid secretion • chloride transmembrane transport
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
152.39 – 152.43 Mb

Chr 11:
56.02 – 56.04 Mb

PubMed search

Neuromedin-U receptor 2 is a protein that in humans is encoded by the NMUR2 gene.^[1]^[2]^[3]

References

↑ Tate CG, Grisshammer R (Jan 1997). "Heterologous expression of G-protein-coupled receptors". Trends Biotechnol 14 (11): 426–30. doi:10.1016/0167-7799(96)10059-7. PMID 8940772.
↑ Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q (Jul 2000). "Identification of receptors for neuromedin U and its role in feeding". Nature 406 (6791): 70–4. doi:10.1038/35017610. PMID 10894543.
↑ "Entrez Gene: NMUR2 neuromedin U receptor 2".

External links

"Neuromedin U Receptors: NMU2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Hosoya M, Moriya T, Kawamata Y, et al. (2000). "Identification and functional characterization of a novel subtype of neuromedin U receptor.". J. Biol. Chem. 275 (38): 29528–32. doi:10.1074/jbc.M004261200. PMID 10887190.
Raddatz R, Wilson AE, Artymyshyn R, et al. (2000). "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.". J. Biol. Chem. 275 (42): 32452–9. doi:10.1074/jbc.M004613200. PMID 10899166.
Shan L, Qiao X, Crona JH, et al. (2001). "Identification of a novel neuromedin U receptor subtype expressed in the central nervous system.". J. Biol. Chem. 275 (50): 39482–6. doi:10.1074/jbc.C000522200. PMID 11010960.
Fernández Alvarez C, Debeljuk L, Díaz Rodríguez E, Díaz López B (2003). "Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin.". Peptides 23 (9): 1617–23. doi:10.1016/S0196-9781(02)00099-2. PMID 12217422.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bhattacharyya S, Luan J, Farooqi IS, et al. (2004). "Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor.". J. Endocrinol. 183 (1): 115–20. doi:10.1677/joe.1.05830. PMID 15525579.
Mori K, Miyazato M, Ida T, et al. (2005). "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.". EMBO J. 24 (2): 325–35. doi:10.1038/sj.emboj.7600526. PMC 545815. PMID 15635449.
Fang L, Zhang M, Li C, et al. (2006). "Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.". Neurosci. Lett. 404 (1–2): 148–53. doi:10.1016/j.neulet.2006.05.034. PMID 16781063.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Adhesion	ADGRG (1 2 3 4 5 6 7)

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

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Neuromedin U receptor 2

See also

References

External links

Further reading