Schwannoma

Schwannoma

Micrograph of a schwannoma showing both a cellular Antoni A area (center and right of image) and a loose paucicellular Antoni B area (left edge of image). HPS stain.
Classification and external resources
Specialty oncology
ICD-10 C72.4
ICD-9-CM 225.1
ICD-O M9560/0
DiseasesDB 33713
MeSH D009442

A schwannoma (also known as an "neurilemoma,"[1]:621 "neuroma,"[2] "neurolemoma,"[2] and "Schwann cell tumor"[2]) is a benign nerve sheath tumor composed of Schwann cells, which normally produce the insulating myelin sheath covering peripheral nerves.

Schwannomas are homogeneous tumors, consisting only of Schwann cells. The tumor cells always stay on the outside of the nerve, but the tumor itself may either push the nerve aside and/or up against a bony structure (thereby possibly causing damage). Schwannomas are relatively slow-growing. For reasons not yet understood, schwannomas are mostly benign and less than 1% become malignant, degenerating into a form of cancer known as neurofibrosarcoma.

Schwannomas can arise from a genetic disorder called neurofibromatosis. They are universally S-100 positive.

Schwannomas can be removed surgically. Recurrences after total removal are rare.

Verocay bodies are seen histologically in schwannomas.

See also

Additional images

References

  1. ↑ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  2. 1 2 3 Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.

See also


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