Sodium–hydrogen antiporter

The sodium–hydrogen antiporter or sodium–hydrogen exchanger is a membrane protein found in many cells, and especially in those of the nephron of the kidney. Specifically in the intercalary cells of the collecting duct. The membrane pump is primarily responsible for maintaining the balance of pH.^[1]

Isoforms

There are several isoforms of the antiporter:

References

External links

Sodium-Hydrogen Exchanger at the US National Library of Medicine Medical Subject Headings (MeSH)

Membrane transport protein: ion pumps, ATPases / ATP synthase (TC 3A2-3A3)

F-, V-, and A-type ATPase (3.A.2)

H+ (F-type)	H⁺ transporting, mitochondrial: ATP5A1 ATP5B ATP5C1 ATP5C2 ATP5D ATP5E ATP5F1 ATP5G1 ATP5G2 ATP5G3 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5L2 ATP5O ATP5S

H+ (V-type)	H⁺ transporting, lysosomal: ATP6AP1 ATP6AP2 ATP6V1A ATP6V1B1 ATP6V1B2 ATP6V1C1 ATP6V1C2 ATP6V1D ATP6V1E1 ATP6V1E2 ATP6V1F ATP6V1G1 ATP6V1G2 ATP6V1G3 ATP6V1H ATP6V0A1 ATP6V0A2 ATP6V0A4 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0D2 ATP6V0E ATP6V0E1 TCIRG1

A-ATPase	found in Archea

P-type ATPase (3.A.3)

3.A.3.1.1: Na⁺/K⁺ transporting: ATP1A1
ATP1A2
ATP1A3
ATP1A4
ATP1B1
ATP1B2
ATP1B3
ATP1B4
ATP1G1

3.A.3.1.2: H+/K+
H⁺/K⁺ exchanging: ATP4A
ATP4B

3.A.3.1.4: H⁺/K⁺ transporting, nongastric: ATP12A

3.A.3.2: Ca+ (SERCA, PMCA, SPCA) / Ca⁺⁺ transporting: ATP2A1
ATP2A2
ATP2A3
ATP2B1
ATP2B2
ATP2B3
ATP2B4
ATP2C1

3.A.3.5: Cu⁺⁺ transporting: ATP7A
ATP7B

3.A.3.8.8: flippase: ATP8A2

Other/ungrouped:

Na+/K+ – H+

Mg⁺⁺ transporting: ATP3
Class I, type 8: ATP8A1
ATP8B1
ATP8B2
ATP8B3
ATP8B4
Class II, type 9: ATP9A
ATP9B
Class V, type 10: ATP10A
ATP10B
ATP10D
Class VI, type 11: ATP11A
ATP11B
ATP11C
type 13: ATP13A1
ATP13A2
ATP13A3
ATP13A4
ATP13A5

see also ATPase disorders

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