NSI-189
 | |
| Systematic (IUPAC) name | |
|---|---|
|
(4-Benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone | |
| Clinical data | |
| Pregnancy category |
|
| Legal status |
|
| Routes of administration | Oral |
| Pharmacokinetic data | |
| Biological half-life | 17.4–20.5 hours[1] |
| Identifiers | |
| CAS Number | 1270138-40-3 |
| PubChem | CID 50922681 |
| ChemSpider | 32701740 |
| Chemical data | |
| Formula | C22H30N4O |
| Molar mass | 366.4998 g/mol |
| |
| |
NSI-189 is an experimental drug being studied by Neuralstem, Inc.[2] Research into NSI-189 has been funded by the Defense Advanced Research Projects Agency (DARPA) and the National Institutes of Health (NIH) for the treatment of major depressive disorder.[3]
Clinical trials
NSI-189 successfully completed a phase 1 clinical trial in 2011 where it was administered to 41 healthy volunteers.[4]
A phase 1b clinical trial for treating major depressive disorder in 24 patients started in 2012 and completed in July 2014.[5][1]
Neuralstem intends to pursue further clinical trials for a variety of neurological conditions, including major depressive disorder, traumatic brain injury, Alzheimer's disease, post-traumatic stress disorder,[3] stroke, and natural cognitive and memory decline in aging.
See also
References
- 1 2 M Fava, K Johe, L Ereshefsky, L G Gertsik, B A English, J A Bilello, L M Thurmond, J Johnstone, B C Dickerson, N Makris, B B Hoeppner, M Flynn, D Mischoulon, G Kinrys, M P Freeman (December 2015). "A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients". Molecular Psychiatry. doi:10.1038/mp.2015.178.
- ↑ CID 50922681 from PubChem
- 1 2 FDA Approves Neuralstem To Treat Final Cohort In NSI-189 Phase Ib Trial In Major Depressive Disorder
- ↑ Single-Dose Pharmacokinetics (PK) Study of Novel Neurogenic Compound NSI-189
- ↑ Multiple-Dose Pharmacokinetics (PK), and Pharmacodynamic (PD) Effect of NSI-189 Phosphate in Depression Patient Subjects
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||
This article is issued from Wikipedia - version of the Monday, December 14, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.