NPR1

Natriuretic peptide receptor 1
Identifiers
Symbols NPR1 ; ANPRA; ANPa; GUC2A; GUCY2A; NPRA
External IDs OMIM: 108960 MGI: 97371 HomoloGene: 37367 ChEMBL: 1988 GeneCards: NPR1 Gene
EC number 4.6.1.2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4881 18160
Ensembl ENSG00000169418 ENSMUSG00000027931
UniProt P16066 P18293
RefSeq (mRNA) NM_000906 NM_008727
RefSeq (protein) NP_000897 NP_032753
Location (UCSC) Chr 1:
153.68 – 153.69 Mb		 Chr 3:
90.45 – 90.47 Mb
PubMed search

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).[1]

It is localized in the kidney[2] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.[2]

References

  1. ↑ "Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)".
  2. 1 2 BioGPS > NPR1 Retrieved Nov 2010 Archived November 27, 2010 at the Wayback Machine

Further reading

  • Pandey KN (2002). "Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments.". Mol. Cell. Biochem. 230 (1–2): 61–72. doi:10.1023/A:1014240006767. PMID 11952097. 
  • Lucarelli K, Iacoviello M, Dessì-Fulgheri P, et al. (2003). "[Natriuretic peptides and essential arterial hypertension]". Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 3 (11): 1085–91. PMID 12506509. 
  • Pandey KN (2005). "Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A". Peptides 26 (6): 985–1000. doi:10.1016/j.peptides.2004.12.020. PMID 15911067. 
  • Garg R, Pandey KN (2005). "Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression". Peptides 26 (6): 1009–23. doi:10.1016/j.peptides.2004.09.022. PMID 15911069. 

See also

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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