NPDC1
| Neural proliferation, differentiation and control, 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | NPDC1 ; CAB; CAB-; CAB-1; CAB1; NPDC-1 | ||||||||||
| External IDs | OMIM: 605798 MGI: 1099802 HomoloGene: 32050 GeneCards: NPDC1 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 56654 | 18146 | |||||||||
| Ensembl | ENSG00000107281 | ENSMUSG00000015094 | |||||||||
| UniProt | Q9NQX5 | Q64322 | |||||||||
| RefSeq (mRNA) | NM_015392 | NM_008721 | |||||||||
| RefSeq (protein) | NP_056207 | NP_032747 | |||||||||
| Location (UCSC) |
Chr 9: 137.04 – 137.05 Mb |
Chr 2: 25.4 – 25.41 Mb | |||||||||
| PubMed search | |||||||||||
Neural proliferation differentiation and control protein 1 is a protein that in humans is encoded by the NPDC1 gene.[1][2]
Interactions
NPDC1 has been shown to interact with E2F1.[3]
References
- ↑ Qu X, Zhang C, Zhai Y, Xing G, Wei H, Yu Y, Wu S, He F (March 2001). "Characterization and tissue expression of a novel human gene npdc1". Gene 264 (1): 37–44. doi:10.1016/S0378-1119(01)00324-9. PMID 11245976.
- ↑ "Entrez Gene: NPDC1 neural proliferation, differentiation and control, 1".
- ↑ Sansal I, Dupont E, Toru D, Evrard C, Rouget P (October 2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687.
Further reading
- Dupont E, Sansal I, Toru D, Evrard C, Rouget P (1997). "[Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors]". C. R. Seances Soc. Biol. Fil. 191 (1): 95–104. PMID 9181131.
- Galiana E, Vernier P, Dupont E, Evrard C, Rouget P (1995). "Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1560–4. doi:10.1073/pnas.92.5.1560. PMC 42559. PMID 7878019.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Iwasaki K, Toyonaga R (2000). "The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission". EMBO J. 19 (17): 4806–16. doi:10.1093/emboj/19.17.4806. PMC 302062. PMID 10970871.
- Sansal I, Dupont E, Toru D, Evrard C, Rouget P (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687.
- Spencer ML, Theodosiou M, Noonan DJ (2004). "NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif". J. Biol. Chem. 279 (35): 37069–78. doi:10.1074/jbc.M402507200. PMID 15229225.
- Evrard C, Caron S, Rouget P (2004). "Functional analysis of the NPDC-1 gene". Gene 343 (1): 153–63. doi:10.1016/j.gene.2004.08.020. PMID 15563841.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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