NLRC3
| NLR family, CARD domain containing 3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | NLRC3 ; CLR16.2; NOD3 | ||||||||||||
| External IDs | OMIM: 615648 MGI: 2444070 HomoloGene: 18720 IUPHAR: 1764 GeneCards: NLRC3 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 197358 | 268857 | |||||||||||
| Ensembl | ENSG00000167984 | ENSMUSG00000049871 | |||||||||||
| UniProt | Q7RTR2 | Q5DU56 | |||||||||||
| RefSeq (mRNA) | NM_178844 | NM_001081280 | |||||||||||
| RefSeq (protein) | NP_849172 | NP_001074749 | |||||||||||
| Location (UCSC) |
Chr 16: 3.54 – 3.58 Mb |
Chr 16: 3.95 – 3.98 Mb | |||||||||||
| PubMed search | |||||||||||||
NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.[1] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.[2]
References
- ↑ Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.
- ↑ Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.
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