NLGN3

Neuroligin 3

Identifiers

NLGN3 ; HNL3

External IDs

OMIM: 300336 MGI: 2444609 HomoloGene: 23133 GeneCards: NLGN3 Gene

Gene ontology
Molecular function	• cholinesterase activity • receptor activity • protein binding • neurexin family protein binding • cell adhesion molecule binding • scaffold protein binding
Cellular component	• extracellular space • integral component of plasma membrane • cell surface • cell junction • endocytic vesicle • dendrite • neuronal cell body • synapse • excitatory synapse • inhibitory synapse
Biological process	• regulation of respiratory gaseous exchange by neurological system process • acetylcholine catabolic process • receptor-mediated endocytosis • neuron cell-cell adhesion • synapse assembly • learning • visual learning • adult behavior • social behavior • synaptic vesicle endocytosis • axon extension • oligodendrocyte differentiation • modulation of synaptic transmission • synapse organization • positive regulation of synapse assembly • positive regulation of synaptic transmission, glutamatergic • rhythmic synaptic transmission • excitatory postsynaptic potential • inhibitory postsynaptic potential • long-term synaptic potentiation • positive regulation of dendritic spine development • negative regulation of dendritic spine morphogenesis • vocalization behavior • negative regulation of excitatory postsynaptic potential • postsynaptic membrane assembly • presynaptic membrane assembly • positive regulation of inhibitory postsynaptic potential • regulation of long-term synaptic potentiation • positive regulation of protein localization to synapse • regulation of N-methyl-D-aspartate selective glutamate receptor activity • regulation of terminal button organization • positive regulation of excitatory postsynaptic potential • positive regulation of synaptic vesicle clustering • positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
71.14 – 71.17 Mb

Chr X:
101.3 – 101.33 Mb

PubMed search

Neuroligin-3 is a protein that in humans is encoded by the NLGN3 gene.^[1]^[2]^[3]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.^[3]

References

↑ Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
↑ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
1 2 "Entrez Gene: NLGN3 neuroligin 3".

Missler M, Fernandez-Chacon R, Südhof TC (1998). "The making of neurexins". J. Neurochem. 71 (4): 1339–47. doi:10.1046/j.1471-4159.1998.71041339.x. PMID 9751164.
Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ...". Curr. Biol. 10 (17): R620–3. doi:10.1016/S0960-9822(00)00663-1. PMID 10996085.
Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–82. doi:10.1074/jbc.271.5.2676. PMID 8576240.
Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95". Science 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515.
Nguyen T, Südhof TC (1997). "Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules". J. Biol. Chem. 272 (41): 26032–9. doi:10.1074/jbc.272.41.26032. PMID 9325340.
Gilbert M, Smith J, Roskams AJ, Auld VJ (2001). "Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia". Glia 34 (3): 151–64. doi:10.1002/glia.1050. PMID 11329178.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMC 1925054. PMID 12669065.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Vincent JB, Kolozsvari D, Roberts WS, et al. (2005). "Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 82–4. doi:10.1002/ajmg.b.30069. PMID 15274046.
Gauthier J, Bonnel A, St-Onge J, et al. (2005). "NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population". Am. J. Med. Genet. B Neuropsychiatr. Genet. 132 (1): 74–5. doi:10.1002/ajmg.b.30066. PMID 15389766.
Yan J, Oliveira G, Coutinho A, et al. (2005). "Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients". Mol. Psychiatry 10 (4): 329–32. doi:10.1038/sj.mp.4001629. PMID 15622415.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Blasi F, Bacchelli E, Pesaresi G, et al. (2006). "Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (3): 220–1. doi:10.1002/ajmg.b.30287. PMID 16508939.
Talebizadeh Z, Lam DY, Theodoro MF, et al. (2006). "Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism". J. Med. Genet. 43 (5): e21. doi:10.1136/jmg.2005.036897. PMC 2564526. PMID 16648374.
Yamakawa H, Oyama S, Mitsuhashi H, et al. (2007). "Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations". Biochem. Biophys. Res. Commun. 355 (1): 41–6. doi:10.1016/j.bbrc.2007.01.127. PMID 17292328.

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NLGN3

References

Further reading