NEU2
| Sialidase 2 (cytosolic sialidase) |
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PDB rendering based on 1snt. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1SNT, 1SO7, 1VCU, 2F0Z, 2F10, 2F11, 2F12, 2F13, 2F24, 2F25, 2F26, 2F27, 2F28, 2F29
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| Identifiers |
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| Symbols |
NEU2 ; SIAL2 |
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| External IDs |
OMIM: 605528 MGI: 1344417 HomoloGene: 3927 ChEMBL: 3200 GeneCards: NEU2 Gene |
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| EC number |
3.2.1.18 |
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| RNA expression pattern |
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More reference expression data |
| Orthologs |
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| Species |
Human |
Mouse |
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| Entrez |
4759 |
23956 |
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| Ensembl |
ENSG00000115488 |
ENSMUSG00000079434 |
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| UniProt |
Q9Y3R4 |
Q9JMH3 |
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| RefSeq (mRNA) |
NM_005383.2 |
NM_001160163.1 |
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| RefSeq (protein) |
NP_005374.2 |
NP_001153635.1 |
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| Location (UCSC) |
Chr 2:
233.9 – 233.9 Mb |
Chr 1:
89.41 – 89.49 Mb |
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| PubMed search |
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Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.[1][2][3]
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.[3]
References
- ↑ Monti E, Preti A, Rossi E, Ballabio A, Borsani G (Jun 1999). "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics 57 (1): 137–143. doi:10.1006/geno.1999.5749. PMID 10191093.
- ↑ Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E (Jan 2004). "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules". J Biol Chem 279 (5): 3169–3179. doi:10.1074/jbc.M308381200. PMID 14613940.
- 1 2 "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)".
Further reading
- Li CY, Yu Q, Ye ZQ, et al. (2007). "A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir". Cell Res. 17 (4): 357–362. doi:10.1038/cr.2007.27. PMID 17426694.
- Chavas LM, Tringali C, Fusi P, et al. (2005). "Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition". J. Biol. Chem. 280 (1): 469–75. doi:10.1074/jbc.M411506200. PMID 15501818.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hart ML, Saifuddin M, Uemura K, et al. (2003). "High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1". AIDS Res. Hum. Retroviruses 18 (17): 1311–1317. doi:10.1089/088922202320886352. PMID 12487819.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bassi MT, Sperandeo MP, Incerti B, et al. (2000). "SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family". Genomics 62 (2): 297–303. doi:10.1006/geno.1999.5978. PMID 10610726.
- Monti E, Preti A, Nesti C, et al. (2000). "Expression of a novel human sialidase encoded by the NEU2 gene". Glycobiology 9 (12): 1313–1321. doi:10.1093/glycob/9.12.1313. PMID 10561456.
- Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. PMC 190813. PMID 8892864.
- Miyagi T, Konno K, Emori Y, et al. (1994). "Molecular cloning and expression of cDNA encoding rat skeletal muscle cytosolic sialidase". J. Biol. Chem. 268 (35): 26435–40. PMID 8253770.
PDB gallery |
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| | 1snt: Structure of the human cytosolic sialidase Neu2 |
| 1so7: Maltose-induced structure of the human cytolsolic sialidase Neu2 |
| 1vcu: Structure of the human cytosolic sialidase Neu2 in complex with the inhibitor DANA |
| 2f0z: Crystal Structure of the Human Sialidase Neu2 in Complex with Zanamivir inhibitor |
| 2f10: Crystal Structure of the Human Sialidase Neu2 in Complex with Peramivir inhibitor |
| 2f11: Crystal Structure of the Human Sialidase Neu2 in Complex with isobutyl ether mimetic Inhibitor |
| 2f12: Crystal Structure of the Human Sialidase Neu2 in Complex with 3- hydroxypropyl ether mimetic Inhibitor |
| 2f13: Crystal Structure of the Human Sialidase Neu2 in Complex with 2',3'- dihydroxypropyl ether mimetic Inhibitor |
| 2f24: Crystal Structure of the Human Sialidase Neu2 E111Q Mutant |
| 2f25: Crystal Structure of the Human Sialidase Neu2 E111Q Mutant in Complex with DANA Inhibitor |
| 2f26: Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant |
| 2f27: Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant in Complex with DANA Inhibitor |
| 2f28: Crystal Structure of the Human Sialidase Neu2 Q116E Mutant |
| 2f29: Crystal Structure of the Human Sialidase Neu2 Q116E Mutant in Complex with DANA Inhibitor |
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