NCOA4
| Nuclear receptor coactivator 4 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | NCOA4 ; ARA70; ELE1; PTC3; RFG | ||||||||||||
| External IDs | OMIM: 601984 MGI: 1350932 HomoloGene: 38052 GeneCards: NCOA4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8031 | 27057 | |||||||||||
| Ensembl | ENSG00000266412 | ENSMUSG00000056234 | |||||||||||
| UniProt | Q13772 | E9PVM8 | |||||||||||
| RefSeq (mRNA) | NM_001145260 | NM_001033988 | |||||||||||
| RefSeq (protein) | NP_001138732 | NP_001029160 | |||||||||||
| Location (UCSC) |
Chr 10: 46.01 – 46.03 Mb |
Chr 14: 32.16 – 32.18 Mb | |||||||||||
| PubMed search | |||||||||||||
Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.[1][2][3]
Interactions
NCOA4 has been shown to interact with:
- Androgen receptor,[2][4][5][6][7][8][9][10][11] and
- Peroxisome proliferator-activated receptor gamma[12]
See also
References
- ↑ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (Feb 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene 9 (2): 509–16. PMID 8290261.
- 1 2 Yeh S, Chang C (May 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proceedings of the National Academy of Sciences of the United States of America 93 (11): 5517–21. doi:10.1073/pnas.93.11.5517. PMC 39278. PMID 8643607.
- ↑ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4".
- ↑ Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B (Jan 1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Molecular Endocrinology 13 (1): 117–28. doi:10.1210/mend.13.1.0214. PMID 9892017.
- ↑ Miyamoto H, Yeh S, Wilding G, Chang C (Jun 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proceedings of the National Academy of Sciences of the United States of America 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157.
- ↑ Lin HK, Yeh S, Kang HY, Chang C (Jun 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proceedings of the National Academy of Sciences of the United States of America 98 (13): 7200–5. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460.
- ↑ Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proceedings of the National Academy of Sciences of the United States of America 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905.
- ↑ Zhou ZX, He B, Hall SH, Wilson EM, French FS (Feb 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Molecular Endocrinology 16 (2): 287–300. doi:10.1210/mend.16.2.0765. PMID 11818501.
- ↑ He B, Minges JT, Lee LW, Wilson EM (Mar 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". The Journal of Biological Chemistry 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876.
- ↑ Gao T, Brantley K, Bolu E, McPhaul MJ (Oct 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Molecular Endocrinology 13 (10): 1645–56. doi:10.1210/mend.13.10.0352. PMID 10517667.
- ↑ He B, Wilson EM (Mar 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Molecular and Cellular Biology 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
- ↑ Heinlein CA, Ting HJ, Yeh S, Chang C (Jun 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167.
External links
Further reading
- Minoletti F, Butti MG, Coronelli S, Miozzo M, Sozzi G, Pilotti S, Tunnacliffe A, Pierotti MA, Bongarzone I (Sep 1994). "The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2". Genes, Chromosomes & Cancer 11 (1): 51–7. doi:10.1002/gcc.2870110108. PMID 7529046.
- Jhiang SM, Smanik PA, Mazzaferri EL (Apr 1994). "Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma". Cancer Letters 78 (1-3): 69–76. doi:10.1016/0304-3835(94)90033-7. PMID 8180971.
- Bongarzone I, Butti MG, Coronelli S, Borrello MG, Santoro M, Mondellini P, Pilotti S, Fusco A, Della Porta G, Pierotti MA (Jun 1994). "Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas". Cancer Research 54 (11): 2979–85. PMID 8187085.
- Bongarzone I, Butti MG, Fugazzola L, Pacini F, Pinchera A, Vorontsova TV, Demidchik EP, Pierotti MA (Jun 1997). "Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas". Genomics 42 (2): 252–9. doi:10.1006/geno.1997.4685. PMID 9192845.
- Miyamoto H, Yeh S, Wilding G, Chang C (Jun 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proceedings of the National Academy of Sciences of the United States of America 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157.
- Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B (Jan 1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Molecular Endocrinology 13 (1): 117–28. doi:10.1210/mend.13.1.0214. PMID 9892017.
- Kang HY, Yeh S, Fujimoto N, Chang C (Mar 1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". The Journal of Biological Chemistry 274 (13): 8570–6. doi:10.1074/jbc.274.13.8570. PMID 10085091.
- Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proceedings of the National Academy of Sciences of the United States of America 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905.
- Heinlein CA, Ting HJ, Yeh S, Chang C (Jun 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167.
- Gao T, Brantley K, Bolu E, McPhaul MJ (Oct 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Molecular Endocrinology 13 (10): 1645–56. doi:10.1210/mend.13.10.0352. PMID 10517667.
- Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Lin HK, Yeh S, Kang HY, Chang C (Jun 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proceedings of the National Academy of Sciences of the United States of America 98 (13): 7200–5. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460.
- Basolo F, Giannini R, Monaco C, Melillo RM, Carlomagno F, Pancrazi M, Salvatore G, Chiappetta G, Pacini F, Elisei R, Miccoli P, Pinchera A, Fusco A, Santoro M (Jan 2002). "Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma". The American Journal of Pathology 160 (1): 247–54. doi:10.1016/S0002-9440(10)64368-4. PMC 1867131. PMID 11786418.
- Zhou ZX, He B, Hall SH, Wilson EM, French FS (Feb 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Molecular Endocrinology 16 (2): 287–300. doi:10.1210/mend.16.2.0765. PMID 11818501.
- Thin TH, Kim E, Yeh S, Sampson ER, Chen YT, Collins LL, Basavappa R, Chang C (Sep 2002). "Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation". The Journal of Biological Chemistry 277 (39): 36499–508. doi:10.1074/jbc.M202824200. PMID 12068007.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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