NBQX
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| Names | |
|---|---|
| IUPAC name
2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline -7-sulfonamide | |
| Identifiers | |
118876-58-7  | |
| ChEMBL | ChEMBL222519 |
| ChemSpider | 2521927 |
| 4264 | |
| Jmol interactive 3D | Image |
| KEGG | C13667 |
| PubChem | 3272524 |
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| Properties | |
| C12H8N4O6S | |
| Molar mass | 336.281 |
| Appearance | brown/red powder |
| Soluble to 100 mM in DMSO | |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione) is an AMPA receptor antagonist.
NBQX blocks AMPA receptors in micromolar concentrations (~10–20 µM) and also blocks kainate receptors. In experiments, it is used to counter glutamate excitotoxicity.[1] NBQX was found to have anticonvulsant activity in rodent seizure models.[2]
As the disodium salt, NBQX is soluble in water at high concentrations (at least up to 100 mM).[3]
See also
References
- ↑ Pitt, D.; Werner, P.; Raine, C. S. (2000). "Glutamate excitotoxicity in a model of multiple sclerosis". Nat Med. 6 (1): 67–70.
- ↑ Yamaguchi, S.; Donevan, S.D.; Rogawski, M.A. (1993). Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models. Epilepsy Res. 15:179–184.
- ↑ Product information at Tocris
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