Monobactam

Aztreonam. (The square is the β-lactam. There is a second thiazole ring, but it is not fused to the β-lactam ring.)

Tigemonam

Monobactams are β-lactam compounds wherein the β-lactam ring is alone and not fused to another ring (in contrast to most other β-lactams, which have at least two rings). They work only against aerobic Gram negative bacteria (e.g., Neisseria, Pseudomonas ).

The only commercially available monobactam antibiotic is aztreonam.

Other examples of monobactams are tigemonam,^[1] nocardicin A, and tabtoxin.

Adverse effects to monobactams can include skin rash and occasional abnormal liver functions.

They have no cross-hypersensitivity reactions with penicillin but like penicillins can trigger seizures in patients with history of seizures.

References

External links

• Monobactams at the US National Library of Medicine Medical Subject Headings (MeSH)