Mincle receptor

Mincle receptor, macrophage inducible Ca2+-dependent (C-type) lectin; CLEC4E is a calcium-dependent lectin that is a receptor for mycobacterial cord factor, trehalose-6,6'-dimycolate (TDM).[1][2] As a C-type lectin, the mincle receptor binds a range of carbohydrate structures, predominantly containing glucose or mannose, and play an important role in recognition of bacterial glycolipids by the immune system. Upon activation by cord factor, Mincle binds the Fc receptor FcγR and Syk. Cord factor also binds and activates the related C-type lectin MCL; CLEC4D.[3]

References

  1. ↑ Moody, DB; Matsunaga, I (2009). "Mincle is a long sought receptor for mycobacterial cord factor.". Journal of Experimental Medicine 206: 2879–88. doi:10.1084/jem.20092533. PMID 20008525.
  2. ↑ Ishikawa, E; Ishikawa T; Morita YS; Toyonaga K; Yamada H; Takeuchi O; Kinoshita T; Akira S; Yoshikai Y; Yamasaki S (2009). "Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.". Journal of Experimental Medicine 206: 2865–8. doi:10.1084/jem.20091750. PMID 20008526.
  3. ↑ Miyake, Y; Toyonaga K; Mori D; Kakuta S; Hoshino Y; Oyamada A; Yamada H; Ono K; Suyama M; Iwakura Y; Yoshikai Y; Yamasaki S (2013). "C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor.". Immunity 38: 1050–1062. doi:10.1016/j.immuni.2013.03.010. PMID 23602766.


This article is issued from Wikipedia - version of the Tuesday, July 14, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.