Methanosarcina-phenazine hydrogenase

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with other, known, acceptors. The systematic name of this enzyme class is hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase. Other names in common use include methanophenazine hydrogenase, and methylviologen-reducing hydrogenase.

References

Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U (1998). "Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1". J. Bacteriol. 180 (8): 2027–32. PMC 107126. PMID 9555882.
Deppenmeier U, Lienard T, Gottschalk G (1999). "Novel reactions involved in energy conservation by methanogenic archaea". FEBS Lett. 457 (3): 291–7. doi:10.1016/S0014-5793(99)01026-1. PMID 10471795.
Beifuss U, Tietze M, Baumer S, Deppenmeier U (2000). "Methanophenazine: Structure, Total Synthesis, and Function of a New Cofactor from Methanogenic Archaea This work was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 416; grants De 488/6-1 and De 488/4-2) and the Fonds der Chemischen Industrie We are grateful to Drs. J. Paust and H. Jaedicke (BASF AG, Ludwigshafen) and Dr. R. K. Muller (Hoffmann-La Roche Ltd., Basel) for generously providing chemicals". Angew. Chem. Int. Ed. Engl. 39 (14): 2470–2472. doi:10.1002/1521-3773(20000717)39:14<2470::AID-ANIE2470>3.0.CO;2-R. PMID 10941105.

Oxidoreductases: Acting on hydrogen as donor (EC 1.12)

1.12.1	Hydrogen dehydrogenase Hydrogen dehydrogenase (NADP+) Hydrogenase (NAD+, ferredoxin)

1.12.2	Cytochrome-c3 hydrogenase

1.12.5	Hydrogen:quinone oxidoreductase

1.12.7	Ferredoxin hydrogenase

1.10.98	Coenzyme F420 hydrogenase 5,10-Methenyltetrahydromethanopterin hydrogenase Methanosarcina-phenazine hydrogenase Sulfhydrogenase

1.10.99	Hydrogenase (acceptor)

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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