Meralluride

Meralluride
Names

IUPAC name [3-[(4-Hydroxy-4-oxobutanoyl)carbamoylamino]-2-methoxypropyl]mercury hydroxide
Identifiers
CAS Number	140-20-5^Y
ChemSpider	19975270^N
Jmol interactive 3D	Image
PubChem	101626
InChI InChI=1S/C9H15N2O5.Hg.H2O/c1-6(16-2)5-10-9(15)11-7(12)3-4-8(13)14;;/h6H,1,3-5H2,2H3,(H,13,14)(H2,10,11,12,15);;1H2/q;+1;/p-1^N Key: ZRXNZKPGLBQLJV-UHFFFAOYSA-M^N InChI=1/C9H15N2O5.Hg.H2O/c1-6(16-2)5-10-9(15)11-7(12)3-4-8(13)14;;/h6H,1,3-5H2,2H3,(H,13,14)(H2,10,11,12,15);;1H2/q;+1;/p-1/rC9H16HgN2O6/c1-18-6(4-10-17)5-11-9(16)12-7(13)2-3-8(14)15/h6,17H,2-5H2,1H3,(H,14,15)(H2,11,12,13,16) Key: ZRXNZKPGLBQLJV-RFUSTNNRAA
SMILES COC(CNC(=O)NC(=O)CCC(=O)O)C[Hg].O
Properties
Chemical formula	C₉H₁₆HgN₂O₆
Molar mass	448.83 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

Meralluride is a mercurial diuretic.^[1]

References

↑ SANABRIA A (April 1963). "Ultrastructural changes produced in the rat kidney by a mercurial diuretic (meralluride)". Br J Pharmacol Chemother 20: 352–61. doi:10.1111/j.1476-5381.1963.tb01474.x. PMC 1703643. PMID 13976179.

Mercury compounds

Mercury(I)

Mercury(II)

Organomercury compounds	Hg(CH₃)₂ Hg(C₂H₅)₂ Hg(C₆H₅)₂ HgC₆H₅CH₃CO₂ HgC₆H₅OB(OH)₂ HgClC₆H₄CO₂H HgOHCH₂CHOCH₃CH₂(NHCO)₂C₂H₄CO₂H HgOHCH₂CHOCH₃CH₂NHCOC₆H₄OCH₂CO₂H Na₂HgOHC₆HOBrC₆H₂OBrOCHC₆H₄CO₂ HgOC₆H₂CH₃NO₂ NaHgC₂H₅SC₆H₄CO₂

Mercury(IV)

HgF₄

Amalgams

Mercury cations

Antihypertensives: diuretics (C03)

Sulfonamides
(and etacrynic acid)

CA inhibitors (at PT)	Acetazolamide

Loop (Na-K-Cl at AL)	Furosemide^# Bumetanide Etacrynic acid Etozoline Muzolimine Piretanide Tienilic acid Torasemide

Thiazides (Na-Cl at DCT, Calcium-sparing)	Altizide Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Epitizide Hydrochlorothiazide^# Hydroflumethiazide Mebutizide Methyclothiazide Polythiazide Trichlormethiazide

Thiazide-likes (primarily DCT)	Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone

Potassium-sparing (at CD)

ESC blockers	Amiloride^# Triamterene Benzamil

Aldosterone antagonists	Spirolactones: Spironolactone^# Eplerenone Potassium canrenoate Canrenone Non-steroidal: Finerenone

Osmotic diuretics (PT, DL)

Vasopressin receptor inhibitors
(DCT and CD)

Other

Ethanol, Isopropanol, 2M2B
mercurial diuretics (Chlormerodrin, Mersalyl, Meralluride)
Theobromine
Cicletanine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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