Medronic acid

Medronic acid
Names

IUPAC name Methanediylbis(phosphonic acid)
Other names Methanediphosphonic acid; Methylenebis(phosphonic acid); Methylene diphosphonate; Medronate; Phosphonomethylphosphonic acid; MDP
Identifiers
CAS Number	1984-15-2^N
ChEBI	CHEBI:43945^N
ChEMBL	ChEMBL180570^Y
ChemSpider	15308^Y
Jmol interactive 3D	Image
KEGG	D04887^Y
PubChem	16124
UNII	73OS0QIN3O^N
InChI InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)^Y Key: MBKDYNNUVRNNRF-UHFFFAOYSA-N^Y
SMILES O=P(O)(O)CP(=O)(O)O
Properties
Chemical formula	CH₆O₆P₂
Molar mass	176.00 g·mol⁻¹
Melting point	199 to 200 °C (390 to 392 °F; 472 to 473 K)^[1]
Hazards
Lethal dose or concentration (LD, LC):
LD₅₀ (Median dose)	45-50 mg/kg (i.v., mice, rabbits)^[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

Not to be confused with mildronate, a clinically used cardioprotective drug that is used for the treatments of angina and myocardial infarction by inhibiting gamma-butyrobetaine dioxygenase.

Medronic acid is the smallest bisphosphonate. Its complex with radioactive technetium, ^99mTc medronic acid, is used in nuclear medicine to detect bone abnormalities, including metastases.

References

1 2 Budavari, Susan, ed. (1996), The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.), Merck, ISBN 0911910123

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