MEX3D
| Mex-3 homolog D (C. elegans) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | MEX3D ; MEX-3D; MEX3; OK/SW-cl.4; RKHD1; RNF193; TINO | ||||||||||||
| External IDs | OMIM: 611009 MGI: 2681847 HomoloGene: 16890 GeneCards: MEX3D Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 399664 | 237400 | |||||||||||
| Ensembl | ENSG00000181588 | ENSMUSG00000048696 | |||||||||||
| UniProt | Q86XN8 | Q3UE17 | |||||||||||
| RefSeq (mRNA) | NM_001174118 | NM_198615 | |||||||||||
| RefSeq (protein) | NP_001167589 | NP_941017 | |||||||||||
| Location (UCSC) |
Chr 19: 1.55 – 1.57 Mb |
Chr 10: 80.38 – 80.39 Mb | |||||||||||
| PubMed search | |||||||||||||
Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.[1][2]
Function
MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.[2]
Structure
MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.[2]
References
- ↑ "Entrez Gene: mex-3 homolog D (C. elegans)".
- 1 2 3 Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. PMID 14769789.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Buchet-Poyau K, Courchet J, Le Hir H, et al. (2007). "Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.". Nucleic Acids Res. 35 (4): 1289–300. doi:10.1093/nar/gkm016. PMC 1851655. PMID 17267406.
This article is issued from Wikipedia - version of the Tuesday, September 01, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.