METTL3
| Methyltransferase like 3 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | METTL3 ; IME4; M6A; MT-A70; Spo8 | ||||||||||||
| External IDs | OMIM: 612472 MGI: 1927165 HomoloGene: 10501 GeneCards: METTL3 Gene | ||||||||||||
| EC number | 2.1.1.62 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 56339 | 56335 | |||||||||||
| Ensembl | ENSG00000165819 | ENSMUSG00000022160 | |||||||||||
| UniProt | Q86U44 | Q8C3P7 | |||||||||||
| RefSeq (mRNA) | NM_019852 | NM_019721 | |||||||||||
| RefSeq (protein) | NP_062826 | NP_062695 | |||||||||||
| Location (UCSC) |
Chr 14: 21.5 – 21.51 Mb |
Chr 14: 52.29 – 52.31 Mb | |||||||||||
| PubMed search | |||||||||||||
N6-adenosine-methyltransferase 70 kDa subunit is an enzyme that in humans is encoded by the METTL3 gene.[1]
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.[1]
References
Further reading
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bujnicki JM, Feder M, Radlinska M, Blumenthal RM (2003). "Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase". J. Mol. Evol. 55 (4): 431–44. doi:10.1007/s00239-002-2339-8. PMID 12355263.
- Leach RA, Tuck MT (2001). "Expression of the mRNA (N6-adenosine)-methyltransferase S-adenosyl-L-methionine binding subunit mRNA in cultured cells". Int. J. Biochem. Cell Biol. 33 (10): 984–99. doi:10.1016/S1357-2725(01)00071-1. PMID 11470232.
- Bokar JA, Shambaugh ME, Polayes D, et al. (1998). "Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase". RNA 3 (11): 1233–47. PMC 1369564. PMID 9409616.
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