MED28
| Mediator complex subunit 28 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MED28 ; 1500003D12Rik; EG1; magicin | ||||||||||||
| External IDs | OMIM: 610311 MGI: 1914249 HomoloGene: 11873 GeneCards: MED28 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 80306 | 66999 | |||||||||||
| Ensembl | ENSG00000118579 | ENSMUSG00000015804 | |||||||||||
| UniProt | Q9H204 | Q920D3 | |||||||||||
| RefSeq (mRNA) | NM_025205 | NM_025895 | |||||||||||
| RefSeq (protein) | NP_079481 | NP_080171 | |||||||||||
| Location (UCSC) |
Chr 4: 17.61 – 17.63 Mb |
Chr 5: 45.52 – 45.53 Mb | |||||||||||
| PubMed search | |||||||||||||
| Med28 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Med28 | ||||||||
| Pfam | PF11594 | ||||||||
| InterPro | IPR021640 | ||||||||
| |||||||||
Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene.[1][2][3] It forms part of the Mediator complex.
Function
Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.[4]
Interactions
MED28 has been shown to interact with Merlin,[2] Grb2[2] and MED26.[5]
See also
References
- ↑ Liu C, Zhang L, Shao ZM, Beatty P, Sartippour M, Lane TF, Barsky SH, Livingston E, Nguyen M (Jan 2002). "Identification of a novel endothelial-derived gene EG-1". Biochemical and Biophysical Research Communications 290 (1): 602–12. doi:10.1006/bbrc.2001.6119. PMID 11779215.
- 1 2 3 Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V (Nov 2004). "Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2". Oncogene 23 (54): 8815–25. doi:10.1038/sj.onc.1208110. PMID 15467741.
- ↑ "Entrez Gene: MED28 mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae)".
- ↑ Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Näär AM, Ramesh V (Nov 2007). "Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation". The Journal of Biological Chemistry 282 (44): 32152–7. doi:10.1074/jbc.M706592200. PMID 17848560.
- ↑ Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
This article incorporates text from the public domain Pfam and InterPro IPR021640
Further reading
- Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
- Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
- Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
- Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- Lu M, Zhang L, Maul RS, Sartippour MR, Norris A, Whitelegge J, Rao JY, Brooks MN (Jul 2005). "The novel gene EG-1 stimulates cellular proliferation". Cancer Research 65 (14): 6159–66. doi:10.1158/0008-5472.CAN-04-4016. PMID 16024617.
- Lee MF, Beauchamp RL, Beyer KS, Gusella JF, Ramesh V (Sep 2006). "Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation". Biochemical and Biophysical Research Communications 348 (3): 826–31. doi:10.1016/j.bbrc.2006.07.126. PMID 16899217.
- Lu M, Zhang L, Sartippour MR, Norris AJ, Brooks MN (Oct 2006). "EG-1 interacts with c-Src and activates its signaling pathway". International Journal of Oncology 29 (4): 1013–8. doi:10.3892/ijo.29.4.1013. PMID 16964398.
- Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Näär AM, Ramesh V (Nov 2007). "Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation". The Journal of Biological Chemistry 282 (44): 32152–7. doi:10.1074/jbc.M706592200. PMID 17848560.
This article is issued from Wikipedia - version of the Sunday, November 22, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.