MEAI

MEAI
Systematic (IUPAC) name
5-Methoxy-2-indanamine
Clinical data
Legal status
  • Undergoing safety testing
Routes of
administration		 Oral
Identifiers
CAS Number 73305-09-6
ATC code None
PubChem CID 12147687
ChemSpider 11591017 YesY
Synonyms 5-Methoxy-2-aminoindane; 2,3-Dihydro-5-methoxy-1H-inden-2-amine; MEAI; 5-MeO-AI; Chaperon
Chemical data
Formula C10H13NO
Molar mass 163.216 g/mol
 NYesY (what is this?)  (verify)

5-Methoxy-2-aminoindane (MEAI, 5-MeO-AI, or Chaperon) is a psychoactive small molecule belonging to the aminoindane class with a mechanism of action described by one patent as being mediated by binding to the dopamine D3 receptor.[1]

It was first prepared by Schering AG in 1956.[2] David Nutt and Amanda Feilding filed a patent application for the drug claiming that it gives people a pleasant intoxication as well as prevent binge drinking.[3][4][5]

MEAI has been available through grey market sources since 2011.[6] At least 2 journalists tried it on themselves and reported to the public: Michael Slezak from New Scientist[7] and Brie Traits from BBC3.[8] Apparently, Nutt has also tried it himself.[9]

The idea of alcohol substitution got public attention a year prior to the announcement of chaperon[10] but apparently, chaperon innovates in that it can be consumed together with alcohol without ill effect.[11]

MEAI is banned in some countries as a structural isomer of methcathinone.

See also

References

  1. ↑ Haadsma-Svensson, Susanne. "2-aminoindans as selective dopamine D3 ligands".
  2. ↑ Verfahren zur Herstellung von analgetisch wirksamen 2-Aminoindanverbindungen, German Patent DE952441, Nov. 15, 1956
  3. ↑ Michael Slezak (31 December 2014). "High and dry? Party drug could target excess drinking". New Scientist. Retrieved 31 December 2014.
  4. ↑ Gray, Richard. "Could a legal high that mimics ecstasy stop people from boozing? Party drug is patented for use as ‘binge mitigation agent’". Daily Mail. Retrieved 19 January 2015.
  5. ↑ Theresa, Fisher. "Doctors Have Discovered the Simplest Way to Quit Drinking — By Doing Drugs". Retrieved 19 January 2015.
  6. ↑ "5-Meo-AI". Retrieved 31 December 2014.
  7. ↑ Slezak, Michael. "A test of chaperon".
  8. ↑ Traits, Brie. "How Safe Are My Drugs?". BBC. BBC3.
  9. ↑ Phillipa, Skett. "Care for a legal high that’s "Chaperon-ed by Imperial"?". Felix Online.
  10. ↑ Nutt, David. "Alcohol without the hangover? It's closer than you think". The Guardian.
  11. ↑ Cormier, Zoe. "Pop a 'sober up' pill or guzzle synthetic booze to avoid hangovers". The Daily Telegraph. Retrieved 20 January 2015.
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