Melanocortin 5 receptor
| Melanocortin 5 receptor | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MC5R ; MC2 | ||||||||||||
| External IDs | OMIM: 600042 MGI: 99420 HomoloGene: 4321 IUPHAR: 286 ChEMBL: 4608 GeneCards: MC5R Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4161 | 17203 | |||||||||||
| Ensembl | ENSG00000176136 | ENSMUSG00000007480 | |||||||||||
| UniProt | P33032 | G3UWB6 | |||||||||||
| RefSeq (mRNA) | NM_005913 | NM_013596 | |||||||||||
| RefSeq (protein) | NP_005904 | NP_038624 | |||||||||||
| Location (UCSC) |
Chr 18: 13.82 – 13.83 Mb |
Chr 18: 68.34 – 68.34 Mb | |||||||||||
| PubMed search | |||||||||||||
Melanocortin receptor 5 is a protein that in humans is encoded by the MC5R gene.[1][2] It is located on the chromosome 18 in the human genome.[2] When the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.[3]
See also
References
- ↑ Chhajlani V, Muceniece R, Wikberg JE (Oct 1993). "Molecular cloning of a novel human melanocortin receptor". Biochem Biophys Res Commun 195 (2): 866–73. doi:10.1006/bbrc.1993.2125. PMID 8396929.
- 1 2 "Entrez Gene: MC5R melanocortin 5 receptor".
- ↑ Thiboutot D, Sivarajah A, Gilliland K, Cong Z, Clawson G (2000). "The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells". Journal of Investigative Dermatology 115 (4): 614–619. doi:10.1046/j.1523-1747.2000.00094.x. PMID 10998132. Retrieved 2008-01-04.
Further reading
- Fathi Z, Iben LG, Parker EM (1995). "Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype.". Neurochem. Res. 20 (1): 107–13. doi:10.1007/BF00995160. PMID 7739752.
- Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). "Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization.". Cytogenet. Cell Genet. 68 (1–2): 79–81. doi:10.1159/000133895. PMID 7956366.
- Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P (1994). "Molecular cloning and characterization of the rat fifth melanocortin receptor". Biochem. Biophys. Res. Commun. 200 (2): 1007–14. doi:10.1006/bbrc.1994.1550. PMID 8179577.
- Gantz I, Shimoto Y, Konda Y, Miwa H, Dickinson CJ, Yamada T (1994). "Molecular cloning, expression, and characterization of a fifth melanocortin receptor". Biochem. Biophys. Res. Commun. 200 (3): 1214–20. doi:10.1006/bbrc.1994.1580. PMID 8185570.
- Chhajlani V (1997). "Distribution of cDNA for melanocortin receptor subtypes in human tissues". Biochem. Mol. Biol. Int. 38 (1): 73–80. PMID 8932521.
- Yang YK, Ollmann MM, Wilson BD, Dickinson C, Yamada T, Barsh GS, Gantz I (1997). "Effects of recombinant agouti-signaling protein on melanocortin action". Mol. Endocrinol. 11 (3): 274–80. doi:10.1210/me.11.3.274. PMID 9058374.
- Frändberg PA, Xu X, Chhajlani V (1997). "Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH". Biochem. Biophys. Res. Commun. 236 (2): 489–92. doi:10.1006/bbrc.1997.6994. PMID 9240466.
- Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I (1999). "Characterization of Agouti-related protein binding to melanocortin receptors". Mol. Endocrinol. 13 (1): 148–55. doi:10.1210/me.13.1.148. PMID 9892020.
- Hatta N, Dixon C, Ray AJ, Phillips SR, Cunliffe WJ, Dale M, Todd C, Meggit S, Birch-MacHin MA, Rees JL (2001). "Expression, candidate gene, and population studies of the melanocortin 5 receptor". J. Invest. Dermatol. 116 (4): 564–70. doi:10.1046/j.0022-202x.2001.01286.x. PMID 11286624.
- Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH (2001). "Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro". J. Med. Chem. 44 (22): 3665–72. doi:10.1021/jm010165y. PMID 11606131.
- Lapinsh M, Veiksina S, Uhlén S, Petrovska R, Mutule I, Mutulis F, Yahorava S, Prusis P, Wikberg JE (2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes". Mol. Pharmacol. 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID 15470082.
- Lohoff FW, Berrettini WH (2006). "Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder". Psychiatr. Genet. 15 (4): 255–8. doi:10.1097/00041444-200512000-00007. PMID 16314755.
- Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ (2007). "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5". Peptides 28 (6): 1191–6. doi:10.1016/j.peptides.2007.02.012. PMC 1955225. PMID 17482720.
External links
- "Melanocortin Receptors: MC5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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