Mitogen-activated protein kinase 9

Mitogen-activated protein kinase 9
Rendering based on PDB 3E7O​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3E7O​, 3NPC​
Identifiers
Symbols	MAPK9 ; JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; PRKM9; SAPK; SAPK1a; p54a; p54aSAPK
External IDs	OMIM: 602896 MGI: 1346862 HomoloGene: 55685 ChEMBL: 4179 GeneCards: MAPK9 Gene
EC number	2.7.11.24
Gene ontology Molecular function • JUN kinase activity • protein binding • ATP binding • transcription factor binding • cysteine-type endopeptidase activator activity involved in apoptotic process • mitogen-activated protein kinase kinase kinase binding Cellular component • nucleoplasm • mitochondrion • cytosol Biological process • release of cytochrome c from mitochondria • positive regulation of protein phosphorylation • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • protein phosphorylation • protein targeting to mitochondrion • activation of cysteine-type endopeptidase activity involved in apoptotic process • response to stress • JNK cascade • JUN phosphorylation • central nervous system development • response to mechanical stimulus • response to toxic substance • positive regulation of gene expression • positive regulation of macrophage derived foam cell differentiation • positive regulation of cell morphogenesis involved in differentiation • response to amine • neuron projection development • positive regulation of prostaglandin biosynthetic process • regulation of protein ubiquitination • positive regulation of prostaglandin secretion • positive regulation of chemokine production • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 5 signaling pathway • toll-like receptor 9 signaling pathway • toll-like receptor 10 signaling pathway • cellular response to UV • TRIF-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • response to drug • regulation of circadian rhythm • innate immune response • positive regulation of nitric oxide biosynthetic process • positive regulation of transcription, DNA-templated • regulation of JNK cascade • response to cadmium ion • rhythmic process • regulation of sequence-specific DNA binding transcription factor activity • stress-activated MAPK cascade • positive regulation of nitric-oxide synthase biosynthetic process • cellular response to lipopolysaccharide • cellular response to interleukin-1 • cellular response to tumor necrosis factor • cellular response to growth factor stimulus • positive regulation of apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5601	26420
Ensembl	ENSG00000050748	ENSMUSG00000020366
UniProt	P45984	Q9WTU6
RefSeq (mRNA)	NM_001135044	NM_001163671
RefSeq (protein)	NP_001128516	NP_001157143
Location (UCSC)	Chr 5: 180.23 – 180.29 Mb	Chr 11: 49.85 – 49.89 Mb
PubMed search

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.^[1]

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation-induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.^[2]

Interactions

Mitogen-activated protein kinase 9 has been shown to interact with:

• Grb2,^[3][4]
• MAPK8IP1,^[5][6]
• MAPK8IP2,^[5]
• MAPK8IP3^[7][8]
• P53,^[9][10] and
• TOB1.^[11]

References

Further reading

External links

• MAP Kinase Resource .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.