MAPK8IP2

Mitogen-activated protein kinase 8 interacting protein 2
Identifiers
Symbols	MAPK8IP2 ; IB-2; IB2; JIP2; PRKM8IPL
External IDs	OMIM: 607755 MGI: 1926555 HomoloGene: 8201 GeneCards: MAPK8IP2 Gene
Gene ontology Molecular function • beta-amyloid binding • MAP-kinase scaffold activity • structural molecule activity • protein binding • kinesin binding • protein kinase binding • protein kinase activator activity • protein complex binding Cellular component • intracellular • cytoplasm • neuronal cell body • protein complex • neuronal postsynaptic density Biological process • MAPK cascade • behavioral fear response • signal complex assembly • JNK cascade • mating behavior • regulation of receptor activity • activation of protein kinase activity • positive regulation of stress-activated MAPK cascade • social behavior • regulation of JNK cascade • nonassociative learning • dendrite morphogenesis • regulation of synaptic transmission, glutamatergic • excitatory postsynaptic potential • regulation of N-methyl-D-aspartate selective glutamate receptor activity • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23542	60597
Ensembl	ENSG00000008735	ENSMUSG00000022619
UniProt	Q13387	Q9ERE9
RefSeq (mRNA)	NM_012324	NM_021921
RefSeq (protein)	NP_036456	NP_068740
Location (UCSC)	Chr 22: 50.6 – 50.61 Mb	Chr 15: 89.45 – 89.46 Mb
PubMed search

C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it.^[1][2] The gene is also known as Islet-Brain-2 (IB2).

This protein is highly expressed in the brain and is almost always deleted in Phelan-McDermid syndrome (PMS). MAPK8IP2 appears to regulate the ratio of AMPA receptors to NMDA receptors at glutamate synapses,^[3] and thus may be an important contributor to the intellectual dysfunction and related neurological manifestations characteristic of PMS.

The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.^[2]

Interactions

MAPK8IP2 has been shown to interact with MAP3K10,^[1] Mitogen-activated protein kinase 9,^[1] LRP2,^[4][5] LRP1,^[4] MAPK8IP3,^[6] MAP3K12,^[1] MAPK8IP1,^[1] MAP2K7^[1][7] and MAP3K11.^[1]

References

Further reading