MAD2L2

MAD2 mitotic arrest deficient-like 2 (yeast)

Rendering based on PDB 3ABD.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MAD2L2 ; MAD2B; POLZ2; REV7
External IDs OMIM: 604094 MGI: 1919140 HomoloGene: 4624 GeneCards: MAD2L2 Gene
Orthologs
Species Human Mouse
Entrez 10459 71890
Ensembl ENSG00000116670 ENSMUSG00000029003
UniProt Q9UI95 Q9D752
RefSeq (mRNA) NM_001127325 NM_001305420
RefSeq (protein) NP_001120797 NP_001292349
Location (UCSC) Chr 1:
11.67 – 11.69 Mb
Chr 4:
148.13 – 148.15 Mb
PubMed search

Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene.[1][2]

Function

MAD2L2 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L2 is a homolog of MAD2L1.[2]

Interactions

MAD2L2 has been shown to interact with:

References

  1. Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C (Aug 1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.
  2. 1 2 "Entrez Gene: MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)".
  3. Nelson KK, Schlöndorff J, Blobel CP (Nov 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343 343 (3): 673–80. doi:10.1042/0264-6021:3430673. PMC 1220601. PMID 10527948.
  4. 1 2 Murakumo Y, Roth T, Ishii H, Rasio D, Numata S, Croce CM, Fishel R (Feb 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6): 4391–7. doi:10.1074/jbc.275.6.4391. PMID 10660610.
  5. 1 2 Murakumo Y, Ogura Y, Ishii H, Numata S, Ichihara M, Croce CM, Fishel R, Takahashi M (Sep 2001). "Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7". J. Biol. Chem. 276 (38): 35644–51. doi:10.1074/jbc.M102051200. PMID 11485998.

Further reading


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