Name | Trade name | Type | Source | Target | Use |
3F8 | | mab | mouse | GD2 | neuroblastoma |
8H9[1] | | mab | mouse | B7-H3 | neuroblastoma, sarcoma, metastatic brain cancers |
Abagovomab[2] | | mab | mouse | CA-125 (imitation) | ovarian cancer |
Abciximab | ReoPro | Fab | chimeric | CD41 (integrin alpha-IIb) | platelet aggregation inhibitor |
Abituzumab[3] | | mab | humanized | CD51 | cancer |
Abrilumab[4] | | mab | human | integrin α4β7 | inflammatory bowel disease, ulcerative colitis, Crohn's disease |
Actoxumab[5] | | mab | human | Clostridium difficile | Clostridium difficile colitis |
Adalimumab | Humira | mab | human | TNF-α | Rheumatoid arthritis, Crohn's Disease, Plaque Psoriasis, Psoriatic Arthritis, Ankylosing Spondylitis, Juvenile Idiopathic Arthritis, Hemolytic disease of the newborn |
Adecatumumab[6] | | mab | human | EpCAM | prostate and breast cancer |
Aducanumab[7] | | mab | human | beta-amyloid | Alzheimer's disease |
Afelimomab | | F(ab')2 | mouse | TNF-α | sepsis |
Afutuzumab[8] | | mab | humanized | CD20 | lymphoma |
Alacizumab pegol[9] | | F(ab')2 | humanized | VEGFR2 | cancer |
ALD518[10] | | ? | humanized | IL-6 | rheumatoid arthritis |
Alemtuzumab[11] | Campath, MabCampath | mab | humanized | CD52 | Multiple sclerosis |
Alirocumab[12] | | mab | human | PCSK9 | hypercholesterolemia |
Altumomab pentetate | Hybri-ceaker | mab | mouse | CEA | colorectal cancer (diagnosis) |
Amatuximab[13] | | mab | chimeric | mesothelin | cancer |
Anatumomab mafenatox | | Fab | mouse | TAG-72 | non-small cell lung carcinoma |
Anetumab ravtansine[3] | | mab | human | MSLN | cancer |
Anifrolumab[14] | | mab | human | interferon α/β receptor | systemic lupus erythematosus |
Anrukinzumab[9] (= IMA-638)[15] | | mab | humanized | IL-13 | ? |
Apolizumab[16] | | mab | humanized | HLA-DR ? | hematological cancers |
Arcitumomab | CEA-Scan | Fab' | mouse | CEA | gastrointestinal cancers (diagnosis) |
Ascrinvacumab[17] | | mab | human | activin receptor-like kinase 1 | cancer |
Aselizumab[18] | | mab | humanized | L-selectin (CD62L) | severely injured patients |
Atezolizumab[19] | | mab | humanized | CD274 | cancer |
Atinumab[20] | | mab | human | RTN4 | ? |
Atlizumab (= tocilizumab) | Actemra, RoActemra | mab | humanized | IL-6 receptor | rheumatoid arthritis |
Atorolimumab | | mab | human | Rhesus factor | hemolytic disease of the newborn |
Bapineuzumab[21] | | mab | humanized | beta amyloid | Alzheimer's disease |
Basiliximab | Simulect | mab | chimeric | CD25 (α chain of IL-2 receptor) | prevention of organ transplant rejections |
Bavituximab[2] | | mab | chimeric | phosphatidylserine | cancer, viral infections |
Bectumomab | LymphoScan | Fab' | mouse | CD22 | non-Hodgkin's lymphoma (detection) |
Begelomab[22] | | mab | mouse | DPP4 | ? |
Belimumab | Benlysta, LymphoStat-B | mab | human | BAFF | non-Hodgkin lymphoma etc. |
Benralizumab | | mab | humanized | CD125 | asthma |
Bertilimumab[18] | | mab | human | CCL11 (eotaxin-1) | severe allergic disorders |
Besilesomab[23] | Scintimun | mab | mouse | CEA-related antigen | inflammatory lesions and metastases (detection) |
Bevacizumab[11] | Avastin | mab | humanized | VEGF-A | metastatic cancer, retinopathy of prematurity |
Bezlotoxumab[24] | | mab | human | Clostridium difficile | Clostridium difficile colitis |
Biciromab | FibriScint | Fab' | mouse | fibrin II, beta chain | thromboembolism (diagnosis) |
Bimagrumab[25][26] | | mab | human | ACVR2B | myostatin inhibitor |
Bimekizumab[27] | | mab | humanized | IL17A and IL17F | ? |
Bivatuzumab mertansine | | mab | humanized | CD44 v6 | squamous cell carcinoma |
Blinatumomab | | BiTE | mouse | CD19 | cancer |
Blosozumab[28] | | mab | humanized | SOST | osteoporosis |
Bococizumab[29] | | mab | humanized | neural apoptosis-regulated proteinase 1 | dyslipidemia |
Brentuximab vedotin[30] | | mab | chimeric | CD30 (TNFRSF8) | hematologic cancers |
Briakinumab[31] | | mab | human | IL-12, IL-23 | psoriasis, rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis |
Brodalumab[32] | | mab | human | IL-17 | inflammatory diseases |
Brolucizumab[19] | | mab | humanized | VEGFA | ? |
Brontictuzumab[22] | | mab | Notch 1 | cancer |
Canakinumab[33] | Ilaris | mab | human | IL-1? | rheumatoid arthritis |
Cantuzumab mertansine | | mab | humanized | mucin CanAg | colorectal cancer etc. |
Cantuzumab ravtansine[28] | | mab | humanized | MUC1 | cancers |
Caplacizumab[34] | | mab | humanized | VWF | thrombotic thrombocytopenic purpura, thrombosis |
Capromab pendetide | Prostascint | mab | mouse | prostatic carcinoma cells | prostate cancer (detection) |
Carlumab[35] | | mab | human | MCP-1 | oncology/immune indications |
Catumaxomab[21] | Removab | 3funct | rat/mouse hybrid | EpCAM, CD3 | ovarian cancer, malignant ascites, gastric cancer |
cBR96-doxorubicin immunoconjugate | | mab | humanized | Lewis-Y antigen | cancer |
Cedelizumab | | mab | humanized | CD4 | prevention of organ transplant rejections, treatment of autoimmune diseases |
Certolizumab pegol[6] | Cimzia | Fab' | humanized | TNF-α | Crohn's disease |
Cetuximab | Erbitux | mab | chimeric | EGFR | metastatic colorectal cancer and head and neck cancer |
Ch.14.18 [1] | | mab | chimeric | ??? | neuroblastoma |
Citatuzumab bogatox[8] | | Fab | humanized | EpCAM | ovarian cancer and other solid tumors |
Cixutumumab | | mab | human | IGF-1 receptor | solid tumors |
Clazakizumab[36] | | mab | humanized | Oryctolagus cuniculus | rheumatoid arthritis |
Clenoliximab | | mab | chimeric | CD4 | rheumatoid arthritis |
Clivatuzumab tetraxetan[37] | hPAM4-Cide | mab | humanized | MUC1 | pancreatic cancer |
Codrituzumab[3] | | mab | humanized | glypican 3 | cancer |
Coltuximab ravtansine[3] | | mab | chimeric | CD19 | cancer |
Conatumumab[8] | | mab | human | TRAIL-R2 | cancer |
Concizumab[25] | | mab | humanized | TFPI | bleeding |
Crenezumab[38] | | mab | humanized | 1-40-β-amyloid | Alzheimer's disease |
CR6261 | | mab | human | Influenza A hemagglutinin | infectious disease/influenza A |
Dacetuzumab[9] | | mab | humanized | CD40 | hematologic cancers |
Daclizumab | Zenapax | mab | humanized | CD25 (α chain of IL-2 receptor) | prevention of organ transplant rejections |
Dalotuzumab[39] | | mab | humanized | insulin-like growth factor I receptor | cancer etc. |
Dapirolizumab pegol[27] | | mab | humanized | CD40 ligand | ? |
Daratumumab[40] | | mab | human | CD38 (cyclic ADP ribose hydrolase) | cancer |
Dectrekumab[19] | | mab | human | IL-13 | ? |
Demcizumab[41] | | mab | humanized | DLL4 | cancer |
Denintuzumab mafodotin[22] | | mab | humanized | CD19 | cancer |
Denosumab[42] | Prolia | mab | human | RANKL | osteoporosis, bone metastases etc. |
Derlotuximab biotin[43] | | mab | chimeric | histone complex | recurrent glioblastoma multiforme |
Detumomab | | mab | mouse | B-lymphoma cell | lymphoma |
Dinutuximab[44] | | mab | chimeric | ganglioside GD2 | neuroblastoma |
Diridavumab[45] | | mab | human | hemagglutinin | influenza A |
Dorlimomab aritox[46] | | F(ab')2 | mouse | ? | ? |
Drozitumab[47] | | mab | human | DR5 | cancer etc. |
Duligotumab[48] | | mab | human | HER3 | ? |
Dupilumab[49] | | mab | human | IL4 | atopic diseases |
Durvalumab[50] | | mab | human | CD274 | cancer |
Dusigitumab[51] | | mab | human | ILGF2 | cancer |
Ecromeximab[16] | | mab | chimeric | GD3 ganglioside | malignant melanoma |
Eculizumab[16] | Soliris | mab | humanized | C5 | paroxysmal nocturnal hemoglobinuria |
Edobacomab | | mab | mouse | endotoxin | sepsis caused by Gram-negative bacteria |
Edrecolomab | Panorex | mab | mouse | EpCAM | colorectal carcinoma |
Efalizumab[52] | Raptiva | mab | humanized | LFA-1 (CD11a) | psoriasis (blocks T-cell migration) |
Efungumab[2] | Mycograb | scFv | human | Hsp90 | invasive Candida infection |
Eldelumab[53] | | mab | human | interferon gamma-induced protein | Crohn's disease, ulcerative colitis |
Elgemtumab[19] | | mab | human | ERBB3 | cancer |
Elotuzumab | | mab | humanized | SLAMF7 | multiple myeloma |
Elsilimomab | | mab | mouse | IL-6 | ? |
Emactuzumab[22] | | mab | humanized | CSF1R | cancer |
Emibetuzumab[54] | | mab | humanized | HHGFR | cancer |
Enavatuzumab[55] | | mab | humanized | TWEAK receptor | cancer etc. |
Enfortumab vedotin[56] | | mab | human | AGS-22M6 | cancer expressing Nectin-4 |
Enlimomab pegol[57] | | mab | mouse | ICAM-1 (CD54) | ? |
Enoblituzumab[58] | | mab | humanized | B7-H3 | cancer |
Enokizumab[59] | | mab | humanized | IL9 | asthma |
Enoticumab[48] | | mab | human | DLL4 | ? |
Ensituximab[60] | | mab | chimeric | 5AC | cancer |
Epitumomab cituxetan[61] | | mab | mouse | episialin | ? |
Epratuzumab | | mab | humanized | CD22 | cancer, SLE |
Erlizumab[62] | | F(ab')2 | humanized | ITGB2 (CD18) | heart attack, stroke, traumatic shock |
Ertumaxomab[21] | Rexomun | 3funct | rat/mouse hybrid | HER2/neu, CD3 | breast cancer etc. |
Etaracizumab | Abegrin | mab | humanized | integrin αvβ3 | melanoma, prostate cancer, ovarian cancer etc. |
Etrolizumab[63] | | mab | humanized | integrin α7 β7 | inflammatory bowel disease |
Evinacumab[64] | | mab | human | angiopoietin 3 | dyslipidemia |
Evolocumab[25] | | mab | human | PCSK9 | hypercholesterolemia |
Exbivirumab[65] | | mab | human | hepatitis B surface antigen | hepatitis B |
Fanolesomab[66] | NeutroSpec | mab | mouse | CD15 | appendicitis (diagnosis) |
Faralimomab | | mab | mouse | interferon receptor | ? |
Farletuzumab | | mab | humanized | folate receptor 1 | ovarian cancer |
Fasinumab[67] | | mab | human | HNGF | acute sciatic pain |
FBTA05[68][69] | Lymphomun | 3funct | rat/mouse hybrid | CD20 | chronic lymphocytic leukaemia |
Felvizumab | | mab | humanized | respiratory syncytial virus | respiratory syncytial virus infection |
Fezakinumab[70][71][72] | | mab | human | IL-22 | rheumatoid arthritis, psoriasis |
Ficlatuzumab[73] | | mab | humanized | HGF | cancer etc. |
Figitumumab | | mab | human | IGF-1 receptor | adrenocortical carcinoma, non-small cell lung carcinoma etc. |
Firivumab[22] | | mab | human | influenza A virus hemagglutinin | ? |
Flanvotumab[74] | | mab | human | TYRP1(glycoprotein 75) | melanoma |
Fletikumab[75] | | mab | human | IL 20 | rheumatoid arthritis |
Fontolizumab[16] | HuZAF | mab | humanized | IFN-γ | Crohn's disease etc. |
Foralumab[76] | | mab | human | CD3 epsilon | ? |
Foravirumab[8] | | mab | human | rabies virus glycoprotein | rabies (prophylaxis) |
Fresolimumab[77] | | mab | human | TGF-β | idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, cancer |
Fulranumab[78] | | mab | human | NGF | pain |
Futuximab[48] | | mab | chimeric | EGFR | ? |
Galiximab | | mab | chimeric | CD80 | B-cell lymphoma |
Ganitumab[79] | | mab | human | IGF-I | cancer |
Gantenerumab[33] | | mab | human | beta amyloid | Alzheimer's disease |
Gavilimomab[62] | | mab | mouse | CD147 (basigin) | graft versus host disease |
Gemtuzumab ozogamicin | Mylotarg | mab | humanized | CD33 | acute myelogenous leukemia |
Gevokizumab[80] | | mab | humanized | IL-1β | diabetes etc. |
Girentuximab[40] | Rencarex | mab | chimeric | carbonic anhydrase 9 (CA-IX) | clear cell renal cell carcinoma[81] |
Glembatumumab vedotin[82][83] | | mab | human | GPNMB | melanoma, breast cancer |
Golimumab[65] | Simponi | mab | human | TNF-α | rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis |
Gomiliximab | | mab | chimeric | CD23 (IgE receptor) | allergic asthma |
Guselkumab[84] | | mab | human | IL23 | psoriasis |
Ibalizumab[33] | | mab | humanized | CD4 | HIV infection |
Ibritumomab tiuxetan | Zevalin | mab | mouse | CD20 | non-Hodgkin's lymphoma |
Icrucumab[85] | | mab | human | VEGFR-1 | cancer etc. |
Idarucizumab[3] | | mab | humanized | dabigatran | reversal of anticoagulant effects of dabigatran |
Igovomab | Indimacis-125 | F(ab')2 | mouse | CA-125 | ovarian cancer (diagnosis) |
IMAB362 | | mab | human | CLDN18.2 | gastrointestinal adenocarcinomas and pancreatic tumor |
Imalumab[22] | | mab | human | MIF | cancer |
Imciromab | Myoscint | mab | mouse | cardiac myosin | cardiac imaging |
Imgatuzumab[48] | | mab | humanized | EGFR | cancer |
Inclacumab[34] | | mab | human | selectin P | ? |
Indatuximab ravtansine[28] | | mab | chimeric | SDC1 | cancer |
Indusatumab vedotin[19] | | mab | human | GUCY2C | cancer |
Infliximab | Remicade | mab | chimeric | TNF-α | rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis, Crohn's disease, ulcerative colitis |
Intetumumab[86][87][88] | | mab | human | CD51 | solid tumors (prostate cancer, melanoma) |
Inolimomab | | mab | mouse | CD25 (α chain of IL-2 receptor) | graft versus host disease |
Inotuzumab ozogamicin[23] | | mab | humanized | CD22 | cancer |
Ipilimumab[42] | Yervoy | mab | human | CD152 | melanoma |
Iratumumab[42] | | mab | human | CD30 (TNFRSF8) | Hodgkin's lymphoma |
Isatuximab[89] | | mab | chimeric | CD38 | cancer |
Itolizumab[76] | | mab | humanized | CD6 | ? |
Ixekizumab[90] | | mab | humanized | IL-17A | autoimmune diseases |
Keliximab | | mab | chimeric | CD4 | chronic asthma |
Labetuzumab[52] | CEA-Cide | mab | humanized | CEA | colorectal cancer |
Lambrolizumab[91] | | mab | humanized | PDCD1 | antineoplastic agent |
Lampalizumab[48] | | mab | humanized | CFD | ? |
Lebrikizumab[92] | | mab | humanized | IL-13 | asthma |
Lemalesomab[62] | | mab | mouse | NCA-90 (granulocyte antigen) | diagnostic agent |
Lenzilumab[22] | | mab | human | CSF2 | ? |
Lerdelimumab[11] | | mab | human | TGF beta 2 | reduction of scarring after glaucoma surgery |
Lexatumumab[2] | | mab | human | TRAIL-R2 | cancer |
Libivirumab[65] | | mab | human | hepatitis B surface antigen | hepatitis B |
Lifastuzumab vedotin[93] | | mab | humanized | phosphate-sodium co-transporter | cancer |
Ligelizumab[48][94] | | mab | humanized | IGHE | severe asthma and chronic spontaneous urticaria |
Lilotomab satetraxetan[19] | | mab | mouse | CD37 | cancer |
Lintuzumab | | mab | humanized | CD33 | cancer |
Lirilumab[48] | | mab | human | KIR2D | ? |
Lodelcizumab[25] | | mab | humanized | PCSK9 | hypercholesterolemia |
Lokivetmab[19] | | mab | veterinary | Canis lupus familiaris IL31 | ? |
Lorvotuzumab mertansine | | mab | humanized | CD56 | cancer |
Lucatumumab[9] | | mab | human | CD40 | multiple myeloma, non-Hodgkin's lymphoma, Hodgkin's lymphoma |
Lulizumab pegol[95] | | mab | humanized | CD28 | autoimmune diseases |
Lumiliximab[6] | | mab | chimeric | CD23 (IgE receptor) | chronic lymphocytic leukemia |
Lumretuzumab[22] | | mab | humanized | ERBB3 | cancer |
Mapatumumab[21] | | mab | human | TRAIL-R1 | cancer |
Margetuximab[96] | | mab | humanized | ch4D5 | cancer |
Maslimomab | | ? | mouse | T-cell receptor | ? |
Mavrilimumab[97] | | mab | human | GMCSF receptor α-chain | rheumatoid arthritis |
Matuzumab[18] | | mab | humanized | EGFR | colorectal, lung and stomach cancer |
Mepolizumab | Bosatria | mab | humanized | IL-5 | asthma and white blood cell diseases |
Metelimumab[66] | | mab | human | TGF beta 1 | systemic scleroderma |
Milatuzumab[9] | | mab | humanized | CD74 | multiple myeloma and other hematological malignancies |
Minretumomab | | mab | mouse | TAG-72 | tumor detection (and therapy?) |
Mirvetuximab soravtansine[98] | | mab | chimeric | folate receptor alpha | cancer |
Mitumomab | | mab | mouse | GD3 ganglioside | small cell lung carcinoma |
Mogamulizumab[99] | | mab | humanized | CCR4 | cancer |
Morolimumab | | mab | human | Rhesus factor | ? |
Motavizumab[2] | Numax | mab | humanized | respiratory syncytial virus | respiratory syncytial virus (prevention) |
Moxetumomab pasudotox[100] | | mab | mouse | CD22 | cancer |
Muromonab-CD3 | Orthoclone OKT3 | mab | mouse | CD3 | prevention of organ transplant rejections |
Nacolomab tafenatox | | Fab | mouse | C242 antigen | colorectal cancer |
Namilumab[20] | | mab | human | CSF2 | ? |
Naptumomab estafenatox[101] | | Fab | mouse | 5T4 | non-small cell lung carcinoma, renal cell carcinoma |
Narnatumab[102] | | mab | human | RON | cancer |
Natalizumab | Tysabri | mab | humanized | integrin α4 | multiple sclerosis, Crohn's disease |
Nebacumab | | mab | human | endotoxin | sepsis |
Necitumumab[103] | | mab | human | EGFR | non-small cell lung carcinoma |
Nemolizumab[19] | | mab | humanized | IL31RA | ? |
Nerelimomab | | mab | mouse | TNF-α | ? |
Nesvacumab[104] | | mab | human | angiopoietin 2 | cancer |
Nimotuzumab[42][105] | Theracim, Theraloc | mab | humanized | EGFR | squamous cell carcinoma, head and neck cancer, nasopharyngeal cancer, glioma |
Nivolumab[106] | | mab | human | PD-1 | cancer |
Nofetumomab merpentan | Verluma | Fab | mouse | ? | cancer (diagnosis) |
Obiltoxaximab[107] | | mab | chimeric | Bacillus anthracis anthrax | Bacillus anthracis spores |
Obinutuzumab |
Gazyva |
mab |
humanized |
CD20 |
Chronic lymphatic leukemia |
Ocaratuzumab[108] | | mab | humanized | CD20 | cancer |
Ocrelizumab[42] | | mab | humanized | CD20 | rheumatoid arthritis, lupus erythematosus etc. |
Odulimomab | | mab | mouse | LFA-1 (CD11a) | prevention of organ transplant rejections, immunological diseases |
Ofatumumab[21] | Arzerra | mab | human | CD20 | chronic lymphocytic leukemia etc. |
Olaratumab | | mab | human | PDGF-R α | cancer |
Olokizumab[76] | | mab | humanized | IL6 | ? |
Omalizumab[62] | Xolair | mab | humanized | IgE Fc region | allergic asthma |
Onartuzumab[109] | | mab | humanized | human scatter factor receptor kinase | cancer |
Ontuxizumab[110] | | mab | chimeric/humanized | TEM1 | cancer |
Opicinumab[111] | | mab | human | LINGO-1 | multiple sclerosis |
Oportuzumab monatox[103] | | scFv | humanized | EpCAM | cancer |
Oregovomab[66] | OvaRex | mab | mouse | CA-125 | ovarian cancer |
Orticumab[48] | | mab | human | oxLDL | ? |
Otelixizumab[9] | | mab | chimeric/humanized | CD3 | diabetes mellitus type 1 |
Otlertuzumab[112] | | mab | humanized | CD37 | cancer |
Oxelumab[113] | | mab | human | OX-40 | asthma |
Ozanezumab[114] | | mab | humanized | NOGO-A | ALS and multiple sclerosis |
Ozoralizumab[115] | | mab | humanized | TNF-α | inflammation |
Pagibaximab[21] | | mab | chimeric | lipoteichoic acid | sepsis (Staphylococcus) |
Palivizumab | Synagis, Abbosynagis | mab | humanized | F protein of respiratory syncytial virus | respiratory syncytial virus (prevention) |
Panitumumab[65] | Vectibix | mab | human | EGFR | colorectal cancer |
Pankomab | | mab | humanized | tumor specific glycosylation of MUC1 | ovarian cancer |
Panobacumab[103] | | mab | human | Pseudomonas aeruginosa | Pseudomonas aeruginosa infection |
Parsatuzumab[48] | | mab | human | EGFL7 | cancer |
Pascolizumab[16] | | mab | humanized | IL-4 | asthma |
Pasotuxizumab[22] | | mab | chimeric/humanized | folate hydrolase | cancer |
Pateclizumab[28] | | mab | humanized | LTA | TNF |
Patritumab[34] | | mab | human | HER3 | cancer |
Pembrolizumab[116] | | mab | humanized | PDCD1 | cancer etc. |
Pemtumomab | Theragyn | ? | mouse | MUC1 | cancer |
Perakizumab[48] | | mab | humanized | IL17A | arthritis |
Pertuzumab | Omnitarg | mab | humanized | HER2/neu | cancer |
Pexelizumab[52] | | scFv | humanized | C5 | reduction of side effects of cardiac surgery |
Pidilizumab[117] | | mab | humanized | PD-1 | cancer and infectious diseases |
Pinatuzumab vedotin[25] | | mab | humanized | CD22 | cancer |
Pintumomab | | mab | mouse | adenocarcinoma antigen | adenocarcinoma (imaging) |
Placulumab[118] | | mab | human | human TNF | ? |
Polatuzumab vedotin[25][119] | | mab | humanized | CD79B | cancer |
Ponezumab[120] | | mab | humanized | human beta-amyloid | Alzheimer's disease |
Priliximab | | mab | chimeric | CD4 | Crohn's disease, multiple sclerosis |
Pritoxaximab[25] | | mab | chimeric | E. coli shiga toxin type-1 | ? |
Pritumumab | | mab | human | vimentin | brain cancer |
PRO 140 | | ? | humanized | CCR5 | HIV infection |
Quilizumab[34] | | mab | humanized | IGHE | asthma |
Tetulomab | | mab | humanized | CD37 | cancer[121] |
Racotumomab[103] | | mab | mouse | N-glycolylneuraminic acid | cancer |
Radretumab[20] | | mab | human | fibronectin extra domain-B | cancer |
Rafivirumab[8] | | mab | human | rabies virus glycoprotein | rabies (prophylaxis) |
Ralpancizumab[122] | | mab | humanized | neural apoptosis-regulated proteinase 1 | dyslipidemia |
Ramucirumab | Cyramza | mab | human | VEGFR2 | solid tumors |
Ranibizumab[6] | Lucentis | Fab | humanized | VEGF-A | macular degeneration (wet form) |
Raxibacumab[23] | | mab | human | anthrax toxin, protective antigen | anthrax (prophylaxis and treatment) |
Refanezumab[123] | | mab | humanized | myelin-associated glycoprotein | recovery of motor function after stroke |
Regavirumab | | mab | human | cytomegalovirus glycoprotein B | cytomegalovirus infection |
Reslizumab[52] | | mab | humanized | IL-5 | inflammations of the airways, skin and gastrointestinal tract |
Rilotumumab[124] | | mab | human | HGF | solid tumors |
Rinucumab[125] | | mab | human | platelet-derived growth factor receptor beta | neovascular age-related macular degeneration |
Rituximab | MabThera, Rituxan | mab | chimeric | CD20 | lymphomas, leukemias, some autoimmune disorders |
Robatumumab | | mab | human | IGF-1 receptor | cancer |
Roledumab[76] | | mab | human | RHD | ? |
Romosozumab[126] | | mab | humanized | sclerostin | osteoporosis |
Rontalizumab[127] | | mab | humanized | IFN-α | systemic lupus erythematosus |
Rovelizumab | LeukArrest | mab | humanized | CD11, CD18 | haemorrhagic shock etc. |
Ruplizumab[11] | Antova | mab | humanized | CD154 (CD40L) | rheumatic diseases |
Sacituzumab govitecan[128] | | mab | humanized | tumor-associated calcium signal transducer 2 | cancer |
Samalizumab[129] | | mab | humanized | CD200 | cancer |
Sarilumab[130] | | mab | human | IL6 | rheumatoid arthritis, ankylosing spondylitis |
Satumomab pendetide | | mab | mouse | TAG-72 | cancer (diagnosis) |
Secukinumab[131] | | mab | human | IL-17A | uveitis, rheumatoid arthritis psoriasis |
Seribantumab[25] | | mab | human | ERBB3 | cancer |
Setoxaximab[25] | | mab | chimeric | E. coli shiga toxin type-2 | ? |
Sevirumab | | ? | human | cytomegalovirus | cytomegalovirus infection |
Sibrotuzumab | | mab | humanized | FAP | cancer |
SGN-CD19A | | mab | humanized | CD19 | acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma |
SGN-CD33A | | mab | humanized | CD33 | Acute myeloid leukemia |
Sifalimumab[132] | | mab | humanized | IFN-α | SLE, dermatomyositis, polymyositis |
Siltuximab | | mab | chimeric | IL-6 | cancer |
Simtuzumab[48] | | mab | humanized | LOXL2 | fibrosis |
Siplizumab[16] | | mab | humanized | CD2 | psoriasis, graft-versus-host disease (prevention) |
Sirukumab[133] | | mab | human | IL-6 | rheumatoid arthritis |
Sofituzumab vedotin[134] | | mab | humanized | CA 125 | ovarian cancer |
Solanezumab[103] | | mab | humanized | beta amyloid | Alzheimer's disease |
Solitomab[34] | | mab | mouse | EpCAM | ? |
Sonepcizumab[135] | | ? | humanized | sphingosine-1-phosphate | choroidal and retinal neovascularization |
Sontuzumab[105] | | mab | humanized | episialin | ? |
Stamulumab[42][105] | | mab | human | myostatin | muscular dystrophy |
Sulesomab | LeukoScan | Fab' | mouse | NCA-90 (granulocyte antigen) | osteomyelitis (imaging) |
Suvizumab[82] | | mab | humanized | HIV-1 | viral infections |
Tabalumab[136] | | mab | human | BAFF | B-cell cancers |
Tacatuzumab tetraxetan | AFP-Cide | mab | humanized | alpha-fetoprotein | cancer |
Tadocizumab[105] | | Fab | humanized | integrin αIIbβ3 | percutaneous coronary intervention |
Talizumab | | mab | humanized | IgE | allergic reaction |
Tanezumab[8] | | mab | humanized | NGF | pain |
Taplitumomab paptox[62] | | mab | mouse | CD19 | cancer |
Tarextumab[137] | | mab | human | Notch receptor | cancer |
Tefibazumab[23] | Aurexis | mab | humanized | clumping factor A | Staphylococcus aureus infection |
Telimomab aritox | | Fab | mouse | ? | ? |
Tenatumomab[9] | | mab | mouse | tenascin C | cancer |
Teneliximab[16] | | mab | chimeric | CD40 | ? |
Teplizumab[33] | | mab | humanized | CD3 | diabetes mellitus type 1 |
Teprotumumab[138] | | mab | human | CD221 | hematologic tumors |
Tesidolumab[19] | | mab | human | C5 | ? |
TGN1412 | | ? | humanized | CD28 | chronic lymphocytic leukemia, rheumatoid arthritis |
Ticilimumab (= tremelimumab) | | mab | human | CTLA-4 | cancer |
Tildrakizumab[139] | | mab | humanized | IL23 | immunologically mediated inflammatory disorders |
Tigatuzumab[9] | | mab | humanized | TRAIL-R2 | cancer |
TNX-650 | | ? | humanized | IL-13 | Hodgkin's lymphoma |
Tocilizumab[6] (= atlizumab) | Actemra, RoActemra | mab | humanized | IL-6 receptor | rheumatoid arthritis |
Toralizumab[16] | | mab | humanized | CD154 (CD40L) | rheumatoid arthritis, lupus nephritis etc. |
Tosatoxumab[3] | | mab | human | Staphylococcus aureus | ? |
Tositumomab | Bexxar | ? | mouse | CD20 | follicular lymphoma |
Tovetumab[140] | | mab | human | CD140a | cancer |
Tralokinumab[141] | | mab | human | IL-13 | asthma etc. |
Trastuzumab | Herceptin | mab | humanized | HER2/neu | breast cancer |
TRBS07[142] | Ektomab | 3funct | ? | GD2 | melanoma |
Tregalizumab[20] | | mab | humanized | CD4 | ? |
Tremelimumab | | mab | human | CTLA-4 | cancer |
Trevogrumab[143] | | mab | human | growth differentiation factor 8 | muscle atrophy due to orthopedic disuse and sarcopenia |
Tucotuzumab celmoleukin[42][105] | | mab | humanized | EpCAM | cancer |
Tuvirumab | | ? | human | hepatitis B virus | chronic hepatitis B |
Ublituximab[20] | | mab | chimeric | MS4A1 | cancer |
Ulocuplumab[144] | | mab | human | C-X-C chemokine receptor type 4 | hematologic malignancies |
Urelumab[145] | | mab | human | 4-1BB | cancer etc. |
Urtoxazumab[6] | | mab | humanized | Escherichia coli | diarrhoea caused by E. coli |
Ustekinumab[8] | Stelara | mab | human | IL-12, IL-23 | multiple sclerosis, psoriasis, psoriatic arthritis |
Vandortuzumab vedotin[19] | | mab | humanized | STEAP1 | cancer |
Vantictumab[146] | | mab | human | Frizzled receptor | cancer |
Vanucizumab[22] | | mab | humanized | angiopoietin 2 | cancer |
Vapaliximab[16] | | mab | chimeric | AOC3 (VAP-1) | ? |
Varlilumab[147] | | mab | human | CD27 | ? |
Vatelizumab[28] | | mab | humanized | ITGA2 | ? |
Vedolizumab | | mab | humanized | integrin α4β7 | Crohn's disease, ulcerative colitis |
Veltuzumab[9] | | mab | humanized | CD20 | non-Hodgkin's lymphoma |
Vepalimomab | | mab | mouse | AOC3 (VAP-1) | inflammation |
Vesencumab[20] | | mab | human | NRP1 | ? |
Visilizumab[62] | Nuvion | mab | humanized | CD3 | Crohn's disease, ulcerative colitis |
Volociximab[21] | | mab | chimeric | integrin α5β1 | solid tumors |
Vorsetuzumab mafodotin[148] | | mab | humanized | CD70 | cancer |
Votumumab | HumaSPECT | mab | human | tumor antigen CTAA16.88 | colorectal tumors |
Zalutumumab[21] | HuMax-EGFr | mab | human | EGFR | squamous cell carcinoma of the head and neck |
Zanolimumab[6] | HuMax-CD4 | mab | human | CD4 | rheumatoid arthritis, psoriasis, T-cell lymphoma |
Zatuximab[48] | | mab | chimeric | HER1 | cancer |
Ziralimumab[62] | | mab | human | CD147 (basigin) | ? |
Zolimomab aritox | | mab | mouse | CD5 | systemic lupus erythematosus, graft-versus-host disease |