Libman–Sacks endocarditis

Libman–Sacks endocarditis
Classification and external resources
Specialty rheumatology
ICD-10 I39, M32.1
ICD-9-CM 710.0
DiseasesDB 29254
eMedicine med/1295
MeSH D008180

Libman–Sacks endocarditis (often misspelled Libmann-Sachs) is a form of nonbacterial endocarditis that is seen in association with systemic lupus erythematosus. It is one of the most common heart-related manifestations of lupus (the most common being inflammation of the fibrous sac surrounding the heart).[1]

It was first described by Emanuel Libman and Benjamin Sacks at Mount Sinai Hospital in New York City in 1924.[2][3] The association between Libman–Sacks endocarditis and antiphospholipid syndrome was first noted in 1985.

Presentation

The vegetations are small and formed from strands of fibrin, neutrophils, lymphocytes, and histiocytes. The mitral valve is typically affected, and the vegetations occur on the ventricular and atrial surface of the valve. Libman-Sacks lesions rarely produce significant valve dysfunction and the lesions only rarely embolize.[4]

Pathology

The pathology is the same as nonbacterial thrombotic endocarditis except focal necrosis with hematoxylin bodies can be found only in Libman–Sacks endocarditis.

References

  1. ↑ "Libman-Sakcs endocarditis". Mosby’s Medical, Nursing & Allied Health Dictionary (Fourth ed.). Mosby-YearBook, Inc. 1994. p. 907.
  2. ↑ Libman, E.; Sacks, B. (1924). "A hitherto undescribed form of valvular and mural endocarditis". Arch Intern Med 33 (6): 701–737. doi:10.1001/archinte.1924.00110300044002.
  3. ↑ "Patient.info: Libman-Sacks Endocarditis". Retrieved 2008-08-11.
  4. ↑ Doherty, N. E.; Siegel, R. J. (1985). "Cardiovascular manifestations of systemic lupus erythematosus". Am Heart J 110 (6): 1257–1265. doi:10.1016/0002-8703(85)90023-7. PMID 3907317.
This article is issued from Wikipedia - version of the Tuesday, October 27, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.