Polidocanol

Polidocanol
Systematic (IUPAC) name
3,6,9,12,15,18,21,24,27-nonaoxanonatriacontan-1-ol
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy
category
  • Topical: allowed
    Injection: contraindication in months 1–3 and after week 36
Legal status
  • OTC (topical), ℞ (injection)
Routes of
administration		 topical, subcutaneous injection
Identifiers
CAS Number 9002-92-0 YesY
3055-99-0
ATC code C05BB02
PubChem CID 656641
ChemSpider 570993 YesY
UNII 0AWH8BFG9A N
KEGG D01993 YesY
ChEMBL CHEMBL1201751 N
Synonyms

 

  • Polydocanol
  • Laureth 9
  • Macrogol lauryl ether
  • Lauromacrogol
  • PEG-9 lauryl alcohol
  • POE-9 lauryl alcohol
  • Dodecylpolyethyleneglycolether
  • Hydroxyl polyethoxy dodecane
  • Oxypolyethoxydodecane
Chemical data
Formula C30H62O10
Molar mass 582.8073 g/mol (predicted)
 NYesY (what is this?)  (verify)

Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused by eczema and dry skin.[1]

The substance is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera, Aethoxysklerol[2] and Varithena.[3] Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.

The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Polidocanol works by damaging the cell lining of blood vessels, causing them to close and eventually be replaced by other types of tissue.[4][5]

Pure polidocanol for pharmaceutical use

References

  1. ↑ "E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12.
  2. ↑ Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com
  3. ↑ "Varithena™ (polidocanol injectable foam) For Intravenous Use. Full Prescribing Information" (PDF). Biocompatibles, Inc. Retrieved 1 October 2015.
  4. ↑ Facts and Companies: Varicose Vein Treatment Approved
  5. ↑ "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.
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