Lanugo

Lanugo
Classification and external resources
ICD-10	Q84.2
ICD-9-CM	757.4
DiseasesDB	30821

Lanugo (/ləˈnuːɡoʊ, -ˈnjuː-/;^[1][2] from Latin lana "wool") is very fine, soft, usually unpigmented, downy hair that is sometimes found on the body of a fetus or newborn baby. It is the first hair to be produced by the fetal hair follicles, and it usually appears at about five months of gestation. It is normally shed before birth, around seven or eight months of gestation, but is sometimes present at birth. It disappears on its own within a few days or weeks.^[3]

It is replaced by hair covering the same surfaces, which is called vellus hair. This hair is finer and more difficult to see. The more visible hair that persists into adulthood is called terminal hair. It forms in specific areas and is hormone dependent.^[4]

Occurrence

In humans

Fetal development

During human development, the lanugo grows on fetuses as a normal part of gestation, but it is usually shed and replaced by vellus hair at about 33 to 36 weeks of gestational age. As the lanugo is shed from the skin, it is normal for the hair to be consumed by the developing fetus, since it drinks from the amniotic fluid and urinates into its environment. As a result, lanugo contributes to the newborn baby's meconium. The presence of lanugo on newborns is not necessarily a sign of premature birth. It is seen on infants born at 39 weeks of gestation, that is, full term.

Lanugo functions as an anchor to hold the vernix caseosa on the skin. Together they protect the delicate fetal skin from being damaged by the amniotic fluid.^[5] The vernix caseosa also helps to prepare the fetus for life outside the womb. It provides lubrication for birth and contributes to thermoregulation, prevention of water loss, and innate immunity. Without the lanugo to anchor the vernix caseosa, these functions would be compromised.^[6]

Malnutrition

Lanugo can be observed in malnourished patients, including those with eating disorders. When found along with other physical symptoms, for example, lanugo can help a physician make a diagnosis of anorexia nervosa or bulimia nervosa.^[7]

Teratoma

It is often found in teratomas (congenital tumours).

In animals

Lanugo is also common on other animals. For example, seals^[8] and elephants^[9][10][11] are often born with a covering of lanugo.

Fetal whales, like humans and all other primates, also have lanugo.

References

External links

• Photo of lanugo in a human infant, The Royal Infirmary of Edinburgh