L-aminoadipate-semialdehyde dehydrogenase

In enzymology, a L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31) is an enzyme that catalyzes the chemical reaction

L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H₂O L-2-aminoadipate + NAD(P)H + H⁺

The 4 substrates of this enzyme are L-2-aminoadipate 6-semialdehyde, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are L-2-aminoadipate, NADH, NADPH, and H⁺.

This enzyme participates in lysine biosynthesis and biodegradation.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase. Other names in common use include:

• aminoadipate semialdehyde dehydrogenase,
• 2-aminoadipate semialdehyde dehydrogenase,
• alpha-aminoadipate-semialdehyde dehydrogenase,
• alpha-aminoadipate reductase,
• 2-aminoadipic semialdehyde dehydrogenase,
• L-alpha-aminoadipate delta-semialdehyde oxidoreductase,
• L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase,
• L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine,
• and dinucleotide oxidoreductase.

References

• Calvert AF, Rodwell VW (1966). "Metabolism of pipecolic acid in a Pseudomonas species. 3 L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase". J. Biol. Chem. 241 (2): 409–14. PMID 4285660.