Ketan J. Patel

KJ Patel

Ketan Patel in 2015, portrait from the Royal Society
Born Ketan Jayakrishna Patel
(1961-12-23) December 23, 1961[1]
Nairobi, Kenya[1]
Nationality
Fields
Institutions
Alma mater
Thesis Antigen presentation by the B cell antigen receptor (1994)
Doctoral advisor Michael Neuberger[5][6]
Notable awards

Website

www2.mrc-lmb.cam.ac.uk/group-leaders/n-to-s/kj-patel/

Ketan Jayakrishna Patel (born 1961)[1] FRS[7] FMedSci MRCP is a Staff scientist at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge.[2][10][11][12][13][14][15][16]

Education

Patel was educated at the Banda School in Nairobi and Marlborough College in Wiltshire.[1] He went on to study Medicine at the Royal Free Hospital where he was awarded a Bachelor of Medicine, Bachelor of Surgery (MBBS) degree in 1986. After working as a Senior House Officer, Surgeon and Registrar,[2] he moved on the University of Cambridge, where he was awarded a PhD in 1994[17] for research into antigens and B cells supervised by Michael Neuberger[5] at the Laboratory of Molecular Biology.

Awards and honours

Patel was elected a Fellow of the Royal Society (FRS) in 2015.[8] His certificate of election reads:

“ KJ Patel has made seminal discoveries on the Fanconi pathway of DNA repair. Deficiencies in this pathway lead to defective development, stem cell attrition and cancer in humans. Patel has unveiled the primary role of the Fanconi pathway in resolving DNA damage caused by aldehydes (whether generated by endogenous metabolism or though oxidation of ingested substances such as ethanol). He has also advanced our knowledge of the molecular mechanism of action of the pathway and thrown light on its roles in preserving blood stem cells as well as in protection from cancer.[7] ”

Patel was also elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2013.[9]

References

  1. 1 2 3 4 PATEL, Dr Ketan Jayakrishna. Who's Who 2016 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
  2. 1 2 3 4 "Ketan J. Patel CV". University of Cambridge. Archived from the original on 2013-07-21.
  3. ↑ Joenje, H; Patel, K. J. (2001). "The emerging genetic and molecular basis of Fanconi anaemia". Nature Reviews Genetics 2 (6): 446–57. doi:10.1038/35076590. PMID 11389461.
  4. ↑ Niedzwiedz, W; Mosedale, G; Johnson, M; Ong, C. Y.; Pace, P; Patel, K. J. (2004). "The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair". Molecular Cell 15 (4): 607–20. doi:10.1016/j.molcel.2004.08.009. PMID 15327776.
  5. 1 2 Patel, K.J.; Neuberger, M.S. (1993). "Antigen presentation by the B cell antigen receptor is driven by the αβ sheath and occurs independently of its cytoplasmic tyrosines". Cell 74 (5): 939–946. doi:10.1016/0092-8674(93)90473-4. PMID 8374958.
  6. ↑ Ketan J. Patel (2013-12-01). "Michael Neuberger obituary: Biochemist who discovered how antibodies are greatly improved". The Guardian. Archived from the original on 2015-03-27.
  7. 1 2 3 "Dr Ketan Patel FMedSci FRS". London: The Royal Society. Archived from the original on 2015-05-02.
  8. 1 2 "Dr Ketan Patel FRS". London: Royal Society. Archived from the original on 2015-11-17.
  9. 1 2 "Dr Ketan Patel FRS FMedSci". London: Academy of Medical Sciences. Archived from the original on 2015-05-12.
  10. ↑ Ketan J. Patel's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  11. ↑ Pace, P; Mosedale, G; Hodskinson, M. R.; Rosado, I. V.; Sivasubramaniam, M; Patel, K. J. (2010). "Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway". Science 329 (5988): 219–23. doi:10.1126/science.1192277. PMID 20538911.
  12. ↑ Crossan, G. P.; Van Der Weyden, L; Rosado, I. V.; Langevin, F; Gaillard, P. H.; McIntyre, R. E.; Sanger Mouse Genetics, Project; Gallagher, F; Kettunen, M. I.; Lewis, D. Y.; Brindle, K; Arends, M. J.; Adams, D. J.; Patel, K. J. (2011). "Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia". Nature Genetics 43 (2): 147–52. doi:10.1038/ng.752. PMC 3624090. PMID 21240276.
  13. ↑ Langevin, F; Crossan, G. P.; Rosado, I. V.; Arends, M. J.; Patel, K. J. (2011). "Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice". Nature 475 (7354): 53–8. doi:10.1038/nature10192. PMID 21734703.
  14. ↑ Joenje, H (2011). "Metabolism: Alcohol, DNA and disease". Nature 475 (7354): 45–6. doi:10.1038/475045a. PMID 21734701.
  15. ↑ Patel, K. J.; Yu, V. P.; Lee, H; Corcoran, A; Thistlethwaite, F. C.; Evans, M. J.; Colledge, W. H.; Friedman, L. S.; Ponder, B. A.; Venkitaraman, A. R. (1998). "Involvement of Brca2 in DNA repair". Molecular Cell 1 (3): 347–57. doi:10.1016/s1097-2765(00)80035-0. PMID 9660919.
  16. ↑ Carpten, J. D.; Faber, A. L.; Horn, C; Donoho, G. P.; Briggs, S. L.; Robbins, C. M.; Hostetter, G; Boguslawski, S; Moses, T. Y.; Savage, S; Uhlik, M; Lin, A; Du, J; Qian, Y. W.; Zeckner, D. J.; Tucker-Kellogg, G; Touchman, J; Patel, K; Mousses, S; Bittner, M; Schevitz, R; Lai, M. H.; Blanchard, K. L.; Thomas, J. E. (2007). "A transforming mutation in the pleckstrin homology domain of AKT1 in cancer". Nature 448 (7152): 439–44. doi:10.1038/nature05933. PMID 17611497.
  17. ↑ Patel, Ketan Jayakrishna (1994). Antigen presentation by the B cell antigen receptor (PhD thesis). University of Cambridge. OCLC 53650905.


This article is issued from Wikipedia - version of the Wednesday, January 27, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.