KPNA6

Karyopherin alpha 6 (importin alpha 7)

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
4UAD

Identifiers

Symbols

KPNA6 ; IPOA7; KPNA7

External IDs

OMIM: 610563 MGI: 1100836 HomoloGene: 22472 GeneCards: KPNA6 Gene

Gene ontology
Molecular function	• protein binding • protein transporter activity
Cellular component	• nucleus • cytoplasm • membrane
Biological process	• NLS-bearing protein import into nucleus • positive regulation of transcription from RNA polymerase II promoter • maternal process involved in female pregnancy
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
32.11 – 32.18 Mb

Chr 4:
129.64 – 129.67 Mb

PubMed search

Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene.^[1]

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.^[2]

References

↑ Kohler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, Gorlich D, Hartmann E (Nov 1999). "Evidence for Distinct Substrate Specificities of Importin α Family Members in Nuclear Protein Import". Mol Cell Biol 19 (11): 7782–91. doi:10.1128/mcb.19.11.7782. PMC 84838. PMID 10523667.
↑ "Entrez Gene: KPNA6 karyopherin alpha 6 (importin alpha 7)".

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Gallay P, Swingler S, Song J, et al. (1995). "HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase". Cell 83 (4): 569–76. doi:10.1016/0092-8674(95)90097-7. PMID 7585960.
Freed EO, Englund G, Martin MA (1995). "Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection". J. Virol. 69 (6): 3949–54. PMC 189124. PMID 7745752.
Gallay P, Swingler S, Aiken C, Trono D (1995). "HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator". Cell 80 (3): 379–88. doi:10.1016/0092-8674(95)90488-3. PMID 7859280.
von Schwedler U, Kornbluth RS, Trono D (1994). "The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 6992–6. doi:10.1073/pnas.91.15.6992. PMC 44324. PMID 8041734.
Heinzinger NK, Bukinsky MI, Haggerty SA, et al. (1994). "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells". Proc. Natl. Acad. Sci. U.S.A. 91 (15): 7311–5. doi:10.1073/pnas.91.15.7311. PMC 44389. PMID 8041786.
Bukrinsky MI, Haggerty S, Dempsey MP, et al. (1993). "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells". Nature 365 (6447): 666–9. doi:10.1038/365666a0. PMID 8105392.
Dubrovsky L, Ulrich P, Nuovo GJ, et al. (1996). "Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention". Mol. Med. 1 (2): 217–30. PMC 2229944. PMID 8529100.
Gallay P, Stitt V, Mundy C, et al. (1996). "Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import". J. Virol. 70 (2): 1027–32. PMC 189908. PMID 8551560.
Bukrinskaya AG, Ghorpade A, Heinzinger NK, et al. (1996). "Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA". Proc. Natl. Acad. Sci. U.S.A. 93 (1): 367–71. doi:10.1073/pnas.93.1.367. PMC 40239. PMID 8552640.
Sato A, Yoshimoto J, Isaka Y, et al. (1996). "Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion". Virology 220 (1): 208–12. doi:10.1006/viro.1996.0302. PMID 8659115.
Popov S, Dubrovsky L, Lee MA, et al. (1996). "Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11859–64. doi:10.1073/pnas.93.21.11859. PMC 38149. PMID 8876228.
Chen CF, Li S, Chen Y, et al. (1997). "The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor". J. Biol. Chem. 271 (51): 32863–8. doi:10.1074/jbc.271.51.32863. PMID 8955125.
Freed EO, Englund G, Maldarelli F, Martin MA (1997). "Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection". Cell 88 (2): 171–3; discussion 173–4. doi:10.1016/S0092-8674(00)81836-X. PMID 9008157.

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KPNA6

References

Further reading