KLK1
| Kallikrein 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
PDB rendering based on 1spj. | |||||||||||||
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | KLK1 ; KLKR; Klk6; hK1 | ||||||||||||
| External IDs | OMIM: 147910 MGI: 97322 HomoloGene: 110727 ChEMBL: 2319 GeneCards: KLK1 Gene | ||||||||||||
| EC number | 3.4.21.35 | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3816 | 18050 | |||||||||||
| Ensembl | ENSG00000167748 | ENSMUSG00000066515 | |||||||||||
| UniProt | P06870 | Q62284 | |||||||||||
| RefSeq (mRNA) | NM_002257 | NM_008693 | |||||||||||
| RefSeq (protein) | NP_002248 | NP_032719 | |||||||||||
| Location (UCSC) |
Chr 19: 50.82 – 50.82 Mb |
Chr 7: 44.07 – 44.07 Mb | |||||||||||
| PubMed search | |||||||||||||
Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene.[1][2][3] KLK1 is a member of the peptidase S1 family.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.[4]
References
- ↑ Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, Shaw D (Feb 1992). "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker". Genomics 11 (1): 77–82. doi:10.1016/0888-7543(91)90103-L. PMID 1684954.
- ↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.
- ↑ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723.
- ↑ "Entrez Gene: KLK1 kallikrein 1".
Further reading
- Clements J, Hooper J, Dong Y, Harvey T (2001). "The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions.". Biol. Chem. 382 (1): 5–14. doi:10.1515/BC.2001.002. PMID 11258672.
- Lottspeich F, Geiger R, Henschen A, Kutzbach C (1980). "N-Terminal amino acid sequence of human urinary kallikrein homology with other serine proteases.". Hoppe-Seyler's Z. Physiol. Chem. 360 (12): 1947–50. PMID 393608.
- Riegman PH, Vlietstra RJ, Suurmeijer L, et al. (1992). "Characterization of the human kallikrein locus.". Genomics 14 (1): 6–11. doi:10.1016/S0888-7543(05)80275-7. PMID 1385301.
- Henttu P, Lukkarinen O, Vihko P (1990). "Expression of the gene coding for human prostate-specific antigen and related hGK-1 in benign and malignant tumors of the human prostate.". Int. J. Cancer 45 (4): 654–60. doi:10.1002/ijc.2910450414. PMID 1691151.
- Qin H, Kemp J, Yip MY, et al. (1992). "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization.". Hum. Hered. 41 (4): 222–6. doi:10.1159/000154005. PMID 1783409.
- Lu HS, Lin FK, Chao L, Chao J (1989). "Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation.". Int. J. Pept. Protein Res. 33 (4): 237–49. doi:10.1111/j.1399-3011.1989.tb01277.x. PMID 2666327.
- Angermann A, Bergmann C, Appelhans H (1990). "Cloning and expression of human salivary-gland kallikrein in Escherichia coli.". Biochem. J. 262 (3): 787–93. PMC 1133342. PMID 2686621.
- Evans BA, Yun ZX, Close JA, et al. (1988). "Structure and chromosomal localization of the human renal kallikrein gene.". Biochemistry 27 (9): 3124–9. doi:10.1021/bi00409a003. PMID 2898948.
- Fukushima D, Kitamura N, Nakanishi S (1986). "Nucleotide sequence of cloned cDNA for human pancreatic kallikrein.". Biochemistry 24 (27): 8037–43. doi:10.1021/bi00348a030. PMID 3004571.
- Kellermann J, Lottspeich F, Geiger R, Deutzmann R (1988). "Human urinary kallikrein--amino acid sequence and carbohydrate attachment sites.". Protein Seq. Data Anal. 1 (3): 177–82. PMID 3163150.
- Takahashi S, Irie A, Katayama Y, et al. (1986). "N-terminal amino acid sequence of human urinary prokallikrein.". J. Biochem. 99 (3): 989–92. PMID 3635530.
- Baker AR, Shine J (1986). "Human kidney kallikrein: cDNA cloning and sequence analysis.". DNA 4 (6): 445–50. doi:10.1089/dna.1985.4.445. PMID 3853975.
- Del Nery E, Chagas JR, Juliano MA, et al. (1996). "Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments.". Biochem. J. 312 (1): 233–8. PMC 1136249. PMID 7492318.
- Chen LM, Richards GP, Chao L, Chao J (1995). "Molecular cloning, purification and in situ localization of human colon kallikrein.". Biochem. J. 307 (2): 481–6. PMC 1136673. PMID 7733886.
- Clements J, Mukhtar A, Ehrlich A, Yap B (1995). "Glandular kallikrein gene expression in the human uterus.". Braz. J. Med. Biol. Res. 27 (8): 1855–63. PMID 7749374.
- Lin FK, Lin CH, Chou CC, et al. (1993). "Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes.". Biochim. Biophys. Acta 1173 (3): 325–8. doi:10.1016/0167-4781(93)90131-v. PMID 7916636.
- Gomes RA, Juliano L, Chagas JR, Hial V (1997). "Characterization of kininogenase activity of an acidic proteinase isolated from human kidney.". Can. J. Physiol. Pharmacol. 75 (6): 757–61. doi:10.1139/cjpp-75-6-757. PMID 9276160.
- Bourgeois L, Brillard-Bourdet M, Deperthes D, et al. (1997). "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2.". J. Biol. Chem. 272 (47): 29590–5. doi:10.1074/jbc.272.47.29590. PMID 9368023.
- Chen VC, Chao L, Chao J (2000). "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis.". Biochim. Biophys. Acta 1479 (1–2): 237–46. doi:10.1016/S0167-4838(00)00044-3. PMID 10862973.
External links
| |||||||||
| ||||||||||||||||||||||||||
This article is issued from Wikipedia - version of the Monday, January 25, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.