KIF2A

Kinesin heavy chain member 2A

PDB rendering based on 2gry.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2GRY

Identifiers

Symbols

KIF2A ; CDCBM3; HK2; KIF2

External IDs

OMIM: 602591 MGI: 108390 HomoloGene: 3320 GeneCards: KIF2A Gene

Gene ontology
Molecular function	• motor activity • microtubule motor activity • protein binding • ATP binding • microtubule binding • ATPase activity
Cellular component	• spindle pole • centrosome • cytosol • kinesin complex • spindle microtubule • membrane • sperm principal piece
Biological process	• mitotic cell cycle • microtubule-based movement • microtubule depolymerization • mitotic spindle organization • small GTPase mediated signal transduction • nervous system development • blood coagulation • metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class II • cell differentiation • cell division • mitotic spindle assembly
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
62.31 – 62.54 Mb

Chr 13:
106.96 – 107.02 Mb

PubMed search

Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene.^[1]^[2]

Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM]^[2]

References

↑ Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D (Jul 1997). "Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique". Genomics 42 (1): 67–73. doi:10.1006/geno.1997.4720. PMID 9177777.
1 2 "Entrez Gene: KIF2A kinesin heavy chain member 2A".

Manning AL, Ganem NJ, Bakhoum SF, et al. (2007). "The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.". Mol. Biol. Cell 18 (8): 2970–9. doi:10.1091/mbc.E07-02-0110. PMC 1949365. PMID 17538014.
Schepis A, Stauber T, Krijnse Locker J (2008). "Kinesin-1 plays multiple roles during the vaccinia virus life cycle.". Cell. Microbiol. 9 (8): 1960–73. doi:10.1111/j.1462-5822.2007.00927.x. PMID 17394562.
Li C, Zheng Y, Qin W, et al. (2006). "A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia.". Neurosci. Lett. 407 (2): 151–5. doi:10.1016/j.neulet.2006.08.025. PMID 16959419.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Ganem NJ, Upton K, Compton DA (2006). "Efficient mitosis in human cells lacking poleward microtubule flux.". Curr. Biol. 15 (20): 1827–32. doi:10.1016/j.cub.2005.08.065. PMID 16243029.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ganem NJ, Compton DA (2004). "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK.". J. Cell Biol. 166 (4): 473–8. doi:10.1083/jcb.200404012. PMC 2172212. PMID 15302853.
Johnson JM, Castle J, Garrett-Engele P, et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.". Science 302 (5653): 2141–4. doi:10.1126/science.1090100. PMID 14684825.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

PDB gallery

2gry: Crystal structure of the human KIF2 motor domain in complex with ADP

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KIF2A

References

Further reading