KIF1C

Kinesin family member 1C

PDB rendering based on 2g1l.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KIF1C ; LTXS1; SATX2; SAX2; SPAX2; SPG58
External IDs OMIM: 603060 MGI: 1098260 HomoloGene: 4821 GeneCards: KIF1C Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10749 16562
Ensembl ENSG00000129250 ENSMUSG00000020821
UniProt O43896 O35071
RefSeq (mRNA) NM_006612 NM_153103
RefSeq (protein) NP_006603 NP_694743
Location (UCSC) Chr 17:
5 – 5.03 Mb
Chr 11:
70.7 – 70.73 Mb
PubMed search

Kinesin-like protein KIF1C is a protein that in humans is encoded by the KIF1C gene.[1][2] Kif1C is a fast, non-processive, plus-end directed microtubule motor.[3] Kif1C transports α5β1-integrins in human cells.[4]

Interactions

KIF1C has been shown to interact with PTPN21[1] and YWHAG.[5]

References

  1. 1 2 Dorner C, Ciossek T, Muller S, Moller PH, Ullrich A, Lammers R (Sep 1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". J Biol Chem 273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. PMID 9685376.
  2. "Entrez Gene: KIF1C kinesin family member 1C".
  3. Rogers KR, Weiss S, Crevel I, Brophy PJ, Geeves M, Cross R (September 2001). "KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry". EMBO J. 20 (18): 5101–13. doi:10.1093/emboj/20.18.5101. PMC 125638. PMID 11566875.
  4. Theisen U, Straube E, Straube A (December 2012). "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions". Dev. Cell 23 (6): 1153–66. doi:10.1016/j.devcel.2012.11.005. PMID 23237952.
  5. Dorner C, Ullrich A, Häring HU, Lammers R (November 1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. Biol. Chem. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.

Further reading

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