Ivan Đikić
Ivan Đikić | |
---|---|
Born |
Zagreb, Croatia | 28 May 1966
Nationality | Croatian |
Fields | Cancer research, Cell biology, Signal transduction, Autophagy, Ubiquitin |
Institutions | Goethe University Frankfurt, University of Split |
Alma mater | |
Thesis | The Role of RAS Messenger in Supervision of Division and Cell Differentiation (1991) |
Doctoral advisor | Krešimir Pavelić |
Known for | Oncogenic signaling, Ubiquitin signaling |
Notable awards |
Gottfried Wilhelm Leibniz Prize (2013) William C. Rose Award (2013) Ernst Jung Prize (2013) German Cancer Prize (2010) AACR Award (2006) |
Ivan Đikić (born in Zagreb, Croatia on 28 May 1966) is Director of the Institute of Biochemistry II at Goethe University Frankfurt. In 1991, he earned his M.D. degree from the Faculty of Medicine at the University of Zagreb. After finishing his medical studies he continued to pursue his Ph.D. thesis in molecular biology at the University of Zagreb and at the New York University School of Medicine until 1995. He continued to work as a postdoctoral fellow in the laboratory of Joseph Schlessinger in New York from 1995 to 1997 before starting his own group at the Ludwig Institute for Cancer Research in Uppsala (Sweden). In 2002, Ivan was appointed as a Professor at Goethe University Frankfurt. He followed in Werner Müller-Esterl's footsteps as Director of the Institute of Biochemistry II in 2009. In addition, Ivan Đikić was the first Scientific Director (2009 - 2013) of the Buchmann Institute for Molecular Life Sciences, a cross-faculty, interdisciplinary institute at Goethe University which was founded as part of the Cluster of Excellence Macromolecular Complexes. He is speaker of the Collaborative Research Center 1177 on selective autophagy, and speaker of the LOEWE program "Ubiquitin Networks". Ivan Đikić holds strong links to his homeland Croatia. He has an affiliation as Professor with the School of Medicine University of Split, where he established a outstation lab in Split University and transferring technologies to Croatia. In addition, Dikic has been recognized by one of the highest civilian honours, The Order of Duke Branimir, bestowed by the President of Croatia. Đikić is member of several academic societies, including the number of organizations including the European Molecular Biology Organization (since 2004), the World Academy of Art and Science (since 2008), German National Academy of Sciences Leopoldina (since 2010), the Croatian Academy of Medical Science, and the European Academy of Sciences.
Research
Ivan Đikić's research focuses on deciphering molecular mechanisms of cellular signaling pathways, which have a high relevance to human diseases such as cancer, neurodegenerative disorders and inflammation. Early on, he started to focus on ubiquitin to understand how this modification controls multiple cellular functions, and managed to prove a concept of ubiquitin signal recognition by specialized domains serving as specific receptors. More recently, his team has revealed the functions of linear ubiquitin chains in pathogen defense and overall immune response. He expanded his research to the field of selective autophagy, recognizing the enormous impact of the LC3/GABARAP signaling network displaying striking mechanistic similarities to ubiquitin. One major focus is on the crosstalk between autophagy and endocytic machineries, and in this context he has gained fundamental insight in autophagic processes at the endoplasmic reticulum (ER-phagy).
Education
Ivan Đikić is strongly dedicated to scientific exchange and education, and has contributed to the organization of many international conferences and workshops. In 1998, he initiated the series of Dubrovnik Cell Signalling Conferences, which has been sponsored by EMBO continuously since 2004. Moreover, he is actively involved in organization of EMBO Meetings (Ubiquitin Meetings in 2015, 2013; Autophagy Meeting 2011, Cellular Microbiology/Cell Biology Meeting in 2010, 2008), EMBO Courses (2012, 2010, 2008, 2006 on Ubiquitin/SUMO; 2010 on Ubiquitin & DNA damage) as well as Keystone and CSH Meetings. In July 2016, he will be hosting the Frankfurt Conference on Ubiquitin and Autophagy together with Volker Dötsch.
Honors and awards
2014/2015 | Vallee Visiting Professorship, Harvard Medical School, Boston, USA |
2013 | William C. Rose Award 2013, American Association for Molecular Biology and Biochemistry for outstanding achievements, Boston, USA |
2013 | Gottfried Wilhelm Leibniz Prize of the German Research Foundation, Bonn, Germany |
2013 | Ernst Jung Prize for Medicine 2013, Jung Foundation for Science and Research, Hamburg, Germany |
2010 | The Order of Duke Branimir for international promotion of Croatia |
2010-2015 | European Research Council (ERC) Advanced Grant, Brüssel, Belgium |
2010 | German Cancer Prize, DKG Berlin, Germany |
2009 | Sir Hans Krebs Prize, Medical Faculty Hannover, Hannover, Germany |
2008 | City of Split Award – Annual Prize for Science, Croatia |
2008 | Award of the International Society of Blood Purification, Brijuni Islands |
2006 | Biomedical Science Prize 2006, Glaxo-Smith-Kline-Foundation, Munich, Germany |
2006 | Binder Innovation Prize, German Society for Cell Biology, Braunschweig, Germany |
2006 | Young Cancer Researcher Award, European Association for Cancer Research, Budapest, Hungary |
2006 | AACR Award for Outstanding Achievement in Cancer Research, Washington, USA |
2002 | Lilla Fernström Award, Lund, Sweden |
2000-2004 | Award of the Strategic Funds for Young Leaders, Sweden |
1997-2003 | Research Award, Boehringer Ingelheim Fonds Germany |
Publications
Ivan Đikić is author to numerous publications in high impact scientific journals. A full list of his contributions can be found here.
External links
- Institute of Biochemistry II
- Goethe University Frankfurt am Main
- CRC 1177 on Selective Autophagy
- LOEWE Program Ub-Net
References
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