Isopropamide

Isopropamide
Systematic (IUPAC) name

4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium
Clinical data
MedlinePlus	a694006
Legal status	US: Rx-only, Unscheduled Unscheduled
Routes of administration	Oral
Identifiers
CAS Number	7492-32-2^N
ATC code	A03AB09
PubChem	CID 3775
DrugBank	DB01625^Y
ChemSpider	3643^Y
UNII	8B9I31H724^Y
ChEMBL	CHEMBL1201232^N
Chemical data
Formula	C₂₃H₃₃N₂O⁺
Molar mass	353.52092 g/mol
SMILES O=C(N)C(c1ccccc1)(c2ccccc2)CC[N+](C(C)C)(C(C)C)C
InChI InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1^Y Key:JTPUMZTWMWIVPA-UHFFFAOYSA-O^Y
^NY (what is this?) (verify)

Isopropamide (R5) is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.

References

Seeherman R, Isopropamide iodide: a long-acting anticholinergic, Del Med J. 1957 Oct;29(10):265-9.
Boss EG Jr, Buchanan GC, Effect of isopropamide iodide on basal gastric secretion in the human, Gastroenterology. 1957 Nov;33(5):730-6.

Drugs for functional gastrointestinal disorders (A03)

Drugs for
functional
bowel disorders

Antimuscarinics

Tertiary amino group	Oxyphencyclimine Camylofin Mebeverine Trimebutine Rociverine Dicycloverine Dihexyverine Difemerine Piperidolate

Quaternary ammonium compounds	Benzilone Mepenzolate Pipenzolate Glycopyrronium Oxyphenonium Penthienate Methantheline Propantheline Otilonium Tridihexethyl Isopropamide Hexocyclium Poldine Bevonium Diphemanil Tiemonium Prifinium Timepidium Fenpiverinium

Phosphodiesterase
inhibitors

Acting on
serotonin receptors

Other

Belladonna
and derivatives
(antimuscarinics)

tertiary amines: Atropine
Hyoscyamine

Propulsives

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