Intramyocellular lipids

Intramyocellular lipids are fats stored in droplets in muscle cells. They provide an important energy source for working muscle. During exercise, a large amount of circulating free fatty acids are directed into muscle cells for energy; during rest, incoming fatty acids are instead stored in the muscle cell as triglycerides for later burning.[1] However, an increase in muscle insulin resistance, caused by obesity, diabetes mellitus type 2, and metabolic syndrome, will result in an excess accumulation of intramyocellular lipids.[2][3]

References

  1. ↑ Schrauwen-Hinderling, V. B.; L. J. C. van Loon, R. Koopman, K. Nicolay, W. H. M. Saris, and M. E. Kooi (December 1, 2003). "Intramyocellular lipid content is increased after exercise in nonexercising human skeletal muscle". Journal of Applied Physiology 95 (6): 2328–2332. doi:10.1152/japplphysiol.00304.2003. PMID 12923116. Cite uses deprecated parameter |coauthors= (help);
  2. ↑ Guo, ZengKui (2007). "Intramyocellular lipid kinetics and insulin resistance". Lipids in Health and Disease 6: 18. doi:10.1186/1476-511X-6-18. PMC 1971250. PMID 17650308. Retrieved 17 January 2013.
  3. ↑ Greco, Aldo V.; Gertrude Mingrone; Annalisa Giancaterini; Melania Manco; Manrico Morroni; Saverio Cinti; Marnie Granzotto; Roberto Vettor; Stefania Camastra; Ele Ferrannini (January 2002). "Insulin Resistance in Morbid Obesity Reversal With Intramyocellular Fat Depletion". Diabetes 51 (1): 144–151. doi:10.2337/diabetes.51.1.144. PMID 11756334.

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